Jeong Heonuk, Kurihara Toshihide, Jiang Xiaoyan, Kondo Shinichiro, Ueno Yusuke, Hayashi Yuki, Lee Deokho, Ikeda Shin-Ichi, Mori Kiwako, Torii Hidemasa, Negishi Kazuno, Tsubota Kazuo
Laboratory of Photobiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan; Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Laboratory of Photobiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan; Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Exp Eye Res. 2023 Mar;228:109414. doi: 10.1016/j.exer.2023.109414. Epub 2023 Feb 9.
The prevalence of myopia has been steadily increasing for several decades, and this condition can cause extensive medical and economic issues in society. Exposure to violet light (VL), a short wavelength (360-400 nm) of visible light from sunlight, has been suggested as an effective preventive and suppressive treatments for the development and progression of myopia. However, the clinical application of VL remains unclear. In this study, we aimed to investigate the preventive and suppressive effects of VL on myopia progression. Various transmittances of VL (40%, 70%, and 100%) were tested in C57BL/6J mice with lens-induced myopia (LIM). Changes in the refractive error, axial length, and choroid thickness during the 3-week LIM were measured. The myopic shift in refractive error and difference in axial length between the 0 and -30 diopter lens was lessened in a transmission-dependent manner. Choroidal thinning, which was observed in myopic conditions, was suppressed by VL exposure and affected by its transmission. The results suggest that myopia progression can be managed using VL transmittance. Therefore, these factors should be considered for the prevention and treatment of myopia.
几十年来，近视的患病率一直在稳步上升，这种情况会在社会上引发广泛的医学和经济问题。暴露于紫光（VL），即阳光中一种短波长（360 - 400纳米）的可见光，已被认为是预防和抑制近视发展及进展的有效治疗方法。然而，VL的临床应用仍不明确。在本研究中，我们旨在探究VL对近视进展的预防和抑制作用。在患有晶状体诱导性近视（LIM）的C57BL/6J小鼠中测试了不同透光率（40%、70%和100%）的VL。测量了3周LIM期间屈光不正、眼轴长度和脉络膜厚度的变化。屈光不正的近视性偏移以及0和 - 30屈光度镜片之间眼轴长度的差异以透光率依赖的方式减小。在近视状态下观察到的脉络膜变薄通过VL暴露得到抑制，并受其透光率影响。结果表明，可以使用VL透光率来控制近视进展。因此，在预防和治疗近视时应考虑这些因素。
