Mori Kiwako, Torii Hidemasa, Hara Yutaka, Hara Michiko, Yotsukura Erisa, Hanyuda Akiko, Negishi Kazuno, Kurihara Toshihide, Tsubota Kazuo
Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Laboratory of Photobiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
J Clin Med. 2021 Nov 22;10(22):5462. doi: 10.3390/jcm10225462.
The fact that outdoor light environment is an important suppressive factor against myopia led us to invent violet light-transmitting eyeglasses (VL glasses) which can transmit violet light (VL), 360-400 nm in wavelength, for the suppression of myopia, and can meanwhile block harmful ultraviolet waves from sunlight. The current study is a double-blinded randomized clinical trial to investigate the myopia-suppressive effect of VL glasses compared to conventional eyeglasses (placebo glasses) that do not transmit VL. The subjects were children aged from 6 to 12 years old, the population in which myopia progression is generally accelerated, and the myopia suppressive effect was followed up for two years in a city in Japan. Periodical ophthalmic examinations, interviews, and measurements of reflection and axial length under mydriasis were performed at the initial visit (the baseline) and at 1, 6, 12, 18, and 24 months. The mean change in axial length in the VL glasses group was significantly smaller than in the placebo glasses group when time for near-work was less than 180 min and when the subjects were limited to those who had never used eyeglasses before this trial ( < 0.01); however, this change was not significant without subgrouping. The suppressive rate for axial elongation in the VL glasses group was 21.4% for two years.
室外光环境是预防近视的重要抑制因素，这一事实促使我们发明了能透射波长为360 - 400nm的紫光以抑制近视，同时还能阻挡阳光中有害紫外线的紫光透射眼镜（VL眼镜）。本研究是一项双盲随机临床试验，旨在探究VL眼镜与不透射紫光的传统眼镜（安慰剂眼镜）相比的近视抑制效果。研究对象为6至12岁的儿童，这一群体近视进展通常较快，在日本一个城市对其近视抑制效果进行了为期两年的随访。在初次就诊（基线）以及第1、6、12、18和24个月时进行定期眼科检查、访谈以及散瞳下的反射和眼轴长度测量。当近距离工作时间少于180分钟且研究对象仅限于本次试验前从未戴过眼镜的人群时，VL眼镜组的眼轴长度平均变化显著小于安慰剂眼镜组（<0.01）；然而，不进行亚组分析时这种变化并不显著。VL眼镜组两年的眼轴伸长抑制率为21.4%。
