Torii Hidemasa, Kurihara Toshihide, Seko Yuko, Negishi Kazuno, Ohnuma Kazuhiko, Inaba Takaaki, Kawashima Motoko, Jiang Xiaoyan, Kondo Shinichiro, Miyauchi Maki, Miwa Yukihiro, Katada Yusaku, Mori Kiwako, Kato Keiichi, Tsubota Kinya, Goto Hiroshi, Oda Mayumi, Hatori Megumi, Tsubota Kazuo
Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; Laboratory of Photobiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Visual Functions Section, Department of Rehabilitation for Sensory Functions, Research Institute, National Rehabilitation Center for Persons with Disabilities, Tokorozawa-shi, Saitama 359-8555, Japan.
EBioMedicine. 2017 Feb;15:210-219. doi: 10.1016/j.ebiom.2016.12.007. Epub 2016 Dec 16.
Prevalence of myopia is increasing worldwide. Outdoor activity is one of the most important environmental factors for myopia control. Here we show that violet light (VL, 360-400nm wavelength) suppresses myopia progression. First, we confirmed that VL suppressed the axial length (AL) elongation in the chick myopia model. Expression microarray analyses revealed that myopia suppressive gene EGR1 was upregulated by VL exposure. VL exposure induced significantly higher upregulation of EGR1 in chick chorioretinal tissues than blue light under the same conditions. Next, we conducted clinical research retrospectively to compare the AL elongation among myopic children who wore eyeglasses (VL blocked) and two types of contact lenses (partially VL blocked and VL transmitting). The data showed the VL transmitting contact lenses suppressed myopia progression most. These results suggest that VL is one of the important outdoor environmental factors for myopia control. Since VL is apt to be excluded from our modern society due to the excessive UV protection, VL exposure can be a preventive strategy against myopia progression.
全球近视患病率正在上升。户外活动是控制近视最重要的环境因素之一。在此我们表明，紫光（VL，波长360 - 400nm）可抑制近视进展。首先，我们证实了紫光在雏鸡近视模型中抑制眼轴长度（AL）伸长。表达微阵列分析显示，暴露于紫光可使近视抑制基因EGR1上调。在相同条件下，与蓝光相比，紫光暴露在雏鸡脉络膜视网膜组织中诱导EGR1的上调显著更高。接下来，我们进行了回顾性临床研究，比较了佩戴眼镜（紫光被阻挡）和两种类型隐形眼镜（部分紫光被阻挡和紫光可透过）的近视儿童的眼轴伸长情况。数据显示，紫光可透过的隐形眼镜对近视进展的抑制作用最强。这些结果表明，紫光为控制近视的重要户外环境因素之一。由于过度的紫外线防护，紫光在现代社会中容易被排除，紫光暴露可以作为预防近视进展的策略。
