胰腺癌患者与慢性胰腺炎患者的临床和生物学数据——单中心比较分析

Clinical and Biological Data in Patients with Pancreatic Cancer vs. Chronic Pancreatitis-A Single Center Comparative Analysis.

作者信息

Gheorghe Gina, Ionescu Vlad Alexandru, Moldovan Horatiu, Diaconu Camelia Cristina

机构信息

Faculty of Medicine, University of Medicine and Pharmacy Carol Davila Bucharest, 050474 Bucharest, Romania.

Gastroenterology Department, Clinical Emergency Hospital of Bucharest, 105402 Bucharest, Romania.

出版信息

Diagnostics (Basel). 2023 Jan 19;13(3):369. doi: 10.3390/diagnostics13030369.

DOI:10.3390/diagnostics13030369

PMID:36766475

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9914010/

Abstract

INTRODUCTION

In some patients with chronic pancreatitis, the diagnosis of pancreatic cancer can be missed. The objective of the study was to identify clinical and paraclinical data with statistical significance in the differential diagnosis between chronic pancreatitis and pancreatic cancer.

MATERIALS AND METHODS

We conducted a retrospective, observational study on a cohort of 120 patients hospitalized over 3 years. The patients were equally distributed in two groups: group A, with 60 patients with pancreatic cancer, and group B, with 60 patients with chronic pancreatitis. The statistical analysis was carried out by using the R program.

RESULTS

The comparative analysis of pancreatic cancer vs. chronic pancreatitis revealed a stronger link between pancreatic cancer, female gender ( = 0.001) and age over 60 years ( < 0.001). Patients with pancreatic cancer had higher serum values of aspartate aminotransferase ( 0.005), alanine aminotransferase ( 0.006), total bilirubin ( < 0.001), direct bilirubin ( < 0.001), alkaline phosphatase ( 0.030), C-reactive protein ( = 0.049) and uric acid ( 0.001), while patients with chronic pancreatitis presented slightly higher values of amylase ( 0.020) and lipase ( 0.029).

CONCLUSIONS

Female gender, advanced age, elevated aminotransferases, cholestasis markers and uric acid were associated with a higher probability of pancreatic cancer.

摘要

引言

在一些慢性胰腺炎患者中，可能会漏诊胰腺癌。本研究的目的是确定在慢性胰腺炎和胰腺癌的鉴别诊断中具有统计学意义的临床和辅助临床数据。

材料与方法

我们对一组在3年期间住院的120例患者进行了一项回顾性观察研究。患者平均分为两组：A组，60例胰腺癌患者；B组，60例慢性胰腺炎患者。使用R程序进行统计分析。

结果

胰腺癌与慢性胰腺炎的对比分析显示，胰腺癌与女性性别（P = 0.001）和60岁以上年龄（P < 0.001）之间存在更强的关联。胰腺癌患者的血清天冬氨酸转氨酶（P = 0.005）、丙氨酸转氨酶（P = 0.006）﹑总胆红素（P < 0.001）﹑直接胆红素（P < 0.001）﹑碱性磷酸酶（P = 0.030）﹑C反应蛋白（P = 0.049）和尿酸（P = 0.001）值较高，而慢性胰腺炎患者的淀粉酶（P = 0.020）和脂肪酶（P = 0.029）值略高。