Reginelli Alfonso, Del Canto Mariateresa, Clemente Alfredo, Gragnano Eduardo, Cioce Fabrizio, Urraro Fabrizio, Martinelli Erika, Cappabianca Salvatore
Radiology and Radiotherapy Unit, Department of Precision Medicine, University of Campania "L. Vanvitelli", Piazza Miraglia 2, 80138 Naples, Italy.
Medical Oncology, Department of Precision Medicine, University of Campania "L. Vanvitelli", Piazza Miraglia 2, 80138 Naples, Italy.
J Clin Med. 2023 Jan 22;12(3):879. doi: 10.3390/jcm12030879.
Imaging assessment of liver lesions is fundamental to predict therapeutic response and improve patient survival rates. Dual-Energy Computed Tomography (DECT) is an increasingly used technique in the oncologic field with many emerging applications. The assessment of iodine concentration within a liver lesion reflects the biological properties of the tumor and provides additional information to radiologists that is normally invisible to the human eye. The possibility to predict tumor aggressiveness and therapeutic response based on quantitative and reproducible parameters obtainable from DECT images could improve clinical decisions and drive oncologists to choose the best therapy according to metastasis biological features. Moreover, in comparison with standard dimensional criteria, DECT provides further data on the cancer microenvironment, especially for patients treated with antiangiogenic-based drugs, in which tumor shrinkage is a late parameter of response. We investigated the predictive role of DECT in the early assessment of liver metastasis response to treatment in comparison with standard dimensional criteria during antiangiogenetic-based therapy.
肝脏病变的影像学评估对于预测治疗反应和提高患者生存率至关重要。双能计算机断层扫描（DECT）是肿瘤学领域中越来越常用的技术，有许多新兴应用。对肝脏病变内碘浓度的评估反映了肿瘤的生物学特性，并为放射科医生提供了肉眼通常看不见的额外信息。基于从DECT图像中获得的定量和可重复参数来预测肿瘤侵袭性和治疗反应的可能性，可以改善临床决策，并促使肿瘤学家根据转移灶的生物学特征选择最佳治疗方案。此外，与标准尺寸标准相比，DECT提供了关于癌症微环境的更多数据，特别是对于接受抗血管生成药物治疗的患者，在这些患者中肿瘤缩小是反应的晚期参数。我们研究了与基于抗血管生成治疗期间的标准尺寸标准相比，DECT在肝脏转移灶治疗反应早期评估中的预测作用。
