Lipkin M, Enker W E, Winawer S J
Gastroenterology Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Cancer Lett. 1987 Oct 30;37(2):153-61. doi: 10.1016/0304-3835(87)90158-3.
Recent measurements have shown increased proliferation of colonic epithelial cells in individuals at heightened risk for cancer of the large intestine. This biomarker has facilitated measurements of the effects of nutritional intervention in studies that are attempting to inhibit tumor development in high-risk individuals. In this study, further measurements were made of the proliferation of rectal epithelial cells, when biopsies were removed from mucosa that had not previously been disturbed by any tapwater or other enema preparations. Progressive increases were found in the numbers of [3H]dThd-labeled epithelial cells in rectal crypts, and in labeling index profiles, in patients having previous sporadic adenomas or colon cancer, compared to individuals who had not developed colonic neoplasms. The most quiescent proliferative equilibrium was found in individuals without previous colonic disease. Findings indicated that 'non-prep' rectal biopsies obtained from the most accessible region of the large intestine, show modifications in the biomarker of cell proliferation paralleling colon cancer risk.
最近的测量结果显示，患大肠癌风险较高的个体结肠上皮细胞增殖增加。在试图抑制高危个体肿瘤发展的研究中，这种生物标志物有助于评估营养干预的效果。在本研究中，当从先前未受到任何自来水或其他灌肠制剂干扰的黏膜中取出活检组织时，对直肠上皮细胞的增殖进行了进一步测量。与未发生结肠肿瘤的个体相比，有散发性腺瘤或结肠癌病史的患者直肠隐窝中[³H]胸苷标记的上皮细胞数量以及标记指数曲线呈进行性增加。在没有结肠疾病病史的个体中发现了最静止的增殖平衡。研究结果表明，从大肠最易接近区域获取的“未预处理”直肠活检显示，细胞增殖生物标志物的变化与结肠癌风险平行。
