Caulier Simon, Nannan Catherine, Gillis Annika, Licciardi Florent, Bragard Claude, Mahillon Jacques
Laboratory of Food and Environmental Microbiology, Earth and Life Institute, Université catholique de Louvain, Louvain-la-Neuve, Belgium.
Laboratory of Phytopathology-Applied Microbiology, Earth and Life Institute, Université catholique de Louvain, Louvain-la-Neuve, Belgium.
Front Microbiol. 2019 Feb 26;10:302. doi: 10.3389/fmicb.2019.00302. eCollection 2019.
Over the last seven decades, applications using members of the group have emerged in both food processes and crop protection industries. Their ability to form survival endospores and the plethora of antimicrobial compounds they produce has generated an increased industrial interest as food preservatives, therapeutic agents and biopesticides. In the growing context of food biopreservation and biological crop protection, this review suggests a comprehensive way to visualize the antimicrobial spectrum described within the group, including volatile compounds. This classification distinguishes the bioactive metabolites based on their biosynthetic pathways and chemical nature: , ribosomal peptides (RPs), volatile compounds, polyketides (PKs), non-ribosomal peptides (NRPs), and hybrids between PKs and NRPs. For each clade, the chemical structure, biosynthesis and antimicrobial activity are described and exemplified. This review aims at constituting a convenient and updated classification of antimicrobial metabolites from the group, whose complex phylogeny is prone to further development.
在过去的七十年里，使用该菌群成员的应用已出现在食品加工和作物保护行业中。它们形成存活芽孢的能力以及所产生的大量抗菌化合物，使其作为食品防腐剂、治疗剂和生物农药在工业上受到越来越多的关注。在食品生物保鲜和生物作物保护不断发展的背景下，本综述提出了一种全面的方法来直观呈现该菌群内所描述的抗菌谱，包括挥发性化合物。这种分类根据生物合成途径和化学性质区分生物活性代谢产物：聚酮化合物（PKs）、核糖体肽（RPs）、挥发性化合物、聚酮化合物、非核糖体肽（NRPs）以及PKs和NRPs之间的杂合体。对于每个进化枝，都描述并举例说明了其化学结构、生物合成和抗菌活性。本综述旨在构建一个方便且最新的该菌群抗菌代谢产物分类，其复杂的系统发育易于进一步发展。
