从 King 中分离得到的生物碱和苯乙烯内酯及其对 -葡萄糖苷酶的抑制活性。
Alkaloids and Styryl lactones from King and Their -Glucosidase Inhibitory Activity.
机构信息
Center of Chemical Innovation for Sustainability (CIS) and School of Science, Mae Fah Luang University, Chiang Rai 57100, Thailand.
Department of Industrial Technology and Innovation Management, Faculty of Science and Technology, Pathumwan Institute of Technology, Bangkok 10330, Thailand.
出版信息
Molecules. 2023 Jan 24;28(3):1158. doi: 10.3390/molecules28031158.
Gonioridleylactam (), a new compound, is a unique dimeric aristolactam isolated from the EtOAc extract of the twigs of King. The structure of gonioridleylactam () consists of two different aristolactams linked together with two methylenedioxy bridges at C-3/C-3' and C-4/C-4', generating a ten-membered ring of [1,3,6,8]tetraoxecine. A new natural product, gonioridleyindole (3-hydroxymethyl-1-methyl-1-benz[]indole-4,9-dione, ), together with eight known compounds () were also isolated from this plant. Their structures were extensively characterized by spectroscopic methods and comparisons were made with the literature. Compounds , , and were evaluated for their -glucosidase inhibitory activity. Of these, 3,5-demethoxypiperolide () displayed the highest -glucosidase inhibitory activity, with an IC value of 1.25 µM.
戈尼瑞内酯（）是一种新化合物，是从 King 树枝的 EtOAc 提取物中分离得到的一种独特的二聚型阿替洛尔。戈尼瑞内酯（）的结构由两个不同的阿替洛尔通过两个亚甲二氧基桥在 C-3/C-3'和 C-4/C-4'连接而成，生成一个由 [1,3,6,8]四氧杂环辛烷组成的十个成员环。从这种植物中还分离出了一种新的天然产物，戈尼瑞吲哚（3-羟甲基-1-甲基-1-苯并[]吲哚-4,9-二酮，），以及另外八种已知化合物（）。通过光谱方法对它们的结构进行了广泛的表征，并与文献进行了比较。对化合物、、和进行了 -葡萄糖苷酶抑制活性评价。其中，3,5-二甲氧基哌咯里啶（）表现出最高的 -葡萄糖苷酶抑制活性，IC 值为 1.25 µM。
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