Institute of Radiation Physics, 1007 Lausanne, Switzerland.
Center of Radiopharmaceutical Sciences ETH_PSI-USZ, Paul Scherrer Institute, 5232 Villigen-PSI, Switzerland.
Molecules. 2023 Jan 31;28(3):1345. doi: 10.3390/molecules28031345.
Sc is a promising radionuclide for positron emission tomography (PET) in nuclear medicine. As a part of the implementation of a production site for Sc, precise knowledge of the activity of the product is necessary. At the Paul Scherrer Institute (PSI) and the University of Bern (UniBE), Sc is produced by enriched CaO-target irradiation with a cyclotron. The two sites use different techniques for activity measurement, namely a dose calibrator at the PSI and a gamma-ray spectrometry system at UniBE and PSI. In this work, the Sc was produced at the PSI, and samples of the product were prepared in dedicated containers for onsite measurements at PSI, UniBE, and the Institute of Radiation Physics (IRA) in Lausanne for precise activity measurement using primary techniques and for the calibration of the reference ionization chambers. An accuracy of 1% was obtained for the activity measurement, allowing for a precise calibration of the dose calibrator and gamma-ray spectrometry of the two production sites. Each production site now has the capability of measuring Sc activity with an accuracy of 2%.
Sc 是核医学正电子发射断层扫描（PET）中很有前途的放射性核素。作为 Sc 生产现场实施的一部分，需要精确了解产品的活度。在保罗谢勒研究所（PSI）和伯尔尼大学（UniBE），通过回旋加速器辐照富钙靶来生产 Sc。这两个站点使用不同的活度测量技术，即在 PSI 使用剂量校准器，在 UniBE 和 PSI 使用伽马射线光谱系统。在这项工作中，Sc 在 PSI 生产，并且在专门的容器中制备了产品样品，以便在 PSI、UniBE 和洛桑辐射物理研究所（IRA）进行原位测量，使用主要技术进行精确的活度测量，并对参考电离室进行校准。活度测量的精度达到了 1%，从而可以精确校准两个生产现场的剂量校准器和伽马射线光谱仪。现在，每个生产现场都有能力以 2%的精度测量 Sc 活度。
