Ramsay Ian S, Pokorny Victor J, Lynn Peter A, Klein Samuel D, Sponheim Scott R
Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, Minnesota.
Department of Psychology University of Minnesota, Minneapolis, Minnesota.
Biol Psychiatry Cogn Neurosci Neuroimaging. 2024 Mar;9(3):337-345. doi: 10.1016/j.bpsc.2023.02.001. Epub 2023 Feb 10.
Neural oscillations support perception, attention, and higher-order decision making. Aberrations in the strength or consistency of these oscillations in response to stimuli may underlie impaired visual perception and attention in schizophrenia. Here, we examined the phase and power of alpha oscillations (8-12 Hz) as well as aspects of beta and theta frequency oscillations during a demanding visual sustained attention task.
Patients with schizophrenia (n = 74) and healthy control participants (n = 68) completed the degraded stimulus continuous performance task during electroencephalography. We used time-frequency analysis to evaluate the consistency (intertrial phase coherence) of the alpha cycle shortly after stimulus presentation (50-250 ms). For oscillation strength, we examined event-related desynchronization in a later window associated with decision making (360-700 ms).
Alpha intertrial phase coherence was reduced in schizophrenia, and similar reductions were observed in theta (4-7 Hz) and beta (13-20 Hz), suggesting a lack of responsiveness in slower oscillations to visual stimuli. Alpha and beta event-related desynchronization were also reduced in schizophrenia and associated with worse task performance, increased symptoms, and poorer cognition, suggesting that limited responsiveness of oscillations is related to impairments in the disorder. Individuals with lower intertrial phase coherence had slower resting-state alpha rhythms consistent with dysfunctional oscillations persisting across default and task-related brain states.
In schizophrenia, abnormalities in the phase consistency and strength of slower oscillations during visual perception are related to symptoms and cognitive functioning. Altered visual perception and impaired attention in the disorder may be the consequence of aberrant slower oscillations that fail to dynamically reset and modulate in response to stimuli.
神经振荡支持感知、注意力和高阶决策。这些振荡对刺激的强度或一致性异常可能是精神分裂症患者视觉感知和注意力受损的基础。在此，我们在一项要求较高的视觉持续注意力任务中，研究了α振荡（8 - 12赫兹）的相位和功率以及β和θ频率振荡的相关方面。
精神分裂症患者（n = 74）和健康对照参与者（n = 68）在脑电图检查期间完成了退化刺激连续性能任务。我们使用时频分析来评估刺激呈现后不久（50 - 250毫秒）α周期的一致性（试间相位相干性）。对于振荡强度，我们在与决策相关的较晚窗口（360 - 700毫秒）中检查了事件相关去同步化。
精神分裂症患者的α试间相位相干性降低，θ（4 - 7赫兹）和β（13 - 20赫兹）也观察到类似降低，表明较慢振荡对视觉刺激缺乏反应性。精神分裂症患者的α和β事件相关去同步化也降低，并且与较差的任务表现、症状增加和认知较差相关，表明振荡的有限反应性与该疾病的损害有关。试间相位相干性较低的个体静息状态下的α节律较慢，这与跨默认和任务相关脑状态持续存在的功能失调振荡一致。
在精神分裂症中，视觉感知期间较慢振荡的相位一致性和强度异常与症状和认知功能有关。该疾病中视觉感知改变和注意力受损可能是由于异常的较慢振荡无法动态重置并响应刺激进行调节所致。
