Suppr超能文献

联合癌症免疫诊疗纳米药物:递送技术与治疗效果

Combined Cancer Immunotheranostic Nanomedicines: Delivery Technologies and Therapeutic Outcomes.

作者信息

Nasser Tasneem A, Adel Rawan, Badr Abdelrahman, Teleb Mohamed, Bekhit Adnan A, Elkhodairy Kadria A, Abdelhamid Ahmed S, Elzoghby Ahmed O

机构信息

Cancer Nanotechnology Research Laboratory (CNRL), Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 5372066, Egypt.

出版信息

ACS Omega. 2023 Jan 27;8(5):4491-4507. doi: 10.1021/acsomega.2c05986. eCollection 2023 Feb 7.

Abstract

Cancer is among the main causes of mortality all over the world. The delayed diagnosis is directly related to the decrease in survival rate. The use of immunotherapy has dramatically changed the treatment outcomes of different types of cancers. However, many patients still do not respond to immunotherapies, and many also suffer from severe immune-related side effects. Recent advances in the fields of nanomedicine bioengineering and in particular imaging offered new approaches which can enhance not only the safety but also the efficacy of immunotherapy. Theranostics has showed great progress as a branch of medicine which integrates both diagnosis and therapy in a single system. The outcomes from animal studies demonstrated an improvement in the diagnostic and immunotherapeutic potential of nanoparticles within the theranostic framework. Herein, we discuss the most recent developments in the application of nanotheranostics for combining tumor imaging and cancer immunotherapies.

摘要

癌症是全球主要死因之一。诊断延迟与生存率降低直接相关。免疫疗法的应用极大地改变了不同类型癌症的治疗结果。然而,许多患者对免疫疗法仍无反应,而且许多患者还遭受严重的免疫相关副作用。纳米医学、生物工程领域,尤其是成像领域的最新进展提供了新的方法,不仅可以提高免疫疗法的安全性,还能提高其疗效。治疗诊断学作为医学的一个分支,在单一系统中整合了诊断和治疗,已取得了巨大进展。动物研究结果表明,在治疗诊断框架内,纳米颗粒的诊断和免疫治疗潜力有所提高。在此,我们讨论纳米治疗诊断学在结合肿瘤成像和癌症免疫疗法应用方面的最新进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b78a/9909687/d785fa88015e/ao2c05986_0001.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验