Rose J E, Hickman C S
Department of Psychiatry and Biobehavioral Sciences, School of Medicine, University of California, Los Angeles.
Chest. 1987 Dec;92(6):1005-8. doi: 10.1378/chest.92.6.1005.
We tested the ability of a citric acid aerosol to simulate the tracheal sensations produced by cigarette smoke and to satisfy smokers' desire for cigarettes. Fifteen smokers rated puffs from their own brand of cigarette, citric acid aerosol, a low tar and nicotine cigarette, and air. To focus on tracheal perceptions and pharmacologic effects of nicotine, we equated visual, olfactory and taste cues across conditions. Subjects rated the citric acid aerosol more similar to their own brand, more desirable, and more satisfying (after a block of puffs) than control puffs of air. It was also rated equal to or better than the low tar and nicotine cigarette. Subjects' own brands were rated best, although puffs of citric acid aerosol were of comparable strength and harshness. The results suggest that a nebulizer delivering citric acid in a fine mist might reduce craving for cigarettes in smokers attempting to quit and may thereby increase cessation rates.
我们测试了柠檬酸气雾剂模拟香烟烟雾产生的气管感觉以及满足吸烟者对香烟渴望的能力。15名吸烟者对自己品牌香烟、柠檬酸气雾剂、低焦油和低尼古丁香烟以及空气的抽吸进行了评分。为了关注尼古丁的气管感知和药理作用，我们在不同条件下使视觉、嗅觉和味觉线索保持一致。与空气对照抽吸相比，受试者认为柠檬酸气雾剂与他们自己的品牌更相似、更令人渴望且更令人满意（在一组抽吸之后）。它的评分也等于或优于低焦油和低尼古丁香烟。尽管柠檬酸气雾剂抽吸的强度和刺激性相当，但受试者自己的品牌评分最高。结果表明，以细雾形式输送柠檬酸的雾化器可能会减少试图戒烟的吸烟者对香烟的渴望，从而可能提高戒烟率。
