载脂蛋白 C3 只有在去脂形式下才能诱导炎症小体激活。
Apolipoprotein C3 induces inflammasome activation only in its delipidated form.
机构信息
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington Medicine Diabetes Institute, University of Washington, Seattle, WA, USA.
Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA, USA.
出版信息
Nat Immunol. 2023 Mar;24(3):408-411. doi: 10.1038/s41590-023-01423-2. Epub 2023 Feb 13.
Abstract
Matters arising regarding the lipidation form of plasma APOC3 that induces an alternative NLRP3 activation pathway.
摘要
有关诱导替代 NLRP3 激活途径的血浆 APOC3 脂化形式的问题。
相似文献
1
Apolipoprotein C3 induces inflammasome activation only in its delipidated form.载脂蛋白 C3 只有在去脂形式下才能诱导炎症小体激活。
Nat Immunol. 2023 Mar;24(3):408-411. doi: 10.1038/s41590-023-01423-2. Epub 2023 Feb 13.
2
Reply to: Apolipoprotein C3 induces inflammasome activation only in its delipidated form.回复：载脂蛋白C3仅以其脱脂形式诱导炎性小体激活。
Nat Immunol. 2023 Mar;24(3):412-413. doi: 10.1038/s41590-023-01424-1. Epub 2023 Feb 13.
3
Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation.载脂蛋白 C3 通过替代炎性小体激活诱导炎症和器官损伤。
Nat Immunol. 2020 Jan;21(1):30-41. doi: 10.1038/s41590-019-0548-1. Epub 2019 Dec 9.
4
Regulation and Function of the Nucleotide Binding Domain Leucine-Rich Repeat-Containing Receptor, Pyrin Domain-Containing-3 Inflammasome in Lung Disease.含核苷酸结合结构域富含亮氨酸重复序列受体、含吡啉结构域的3炎性小体在肺部疾病中的调控与功能
Am J Respir Cell Mol Biol. 2016 Feb;54(2):151-60. doi: 10.1165/rcmb.2015-0231TR.
5
High glucose induces pyroptosis of retinal microglia through NLPR3 inflammasome signaling.高葡萄糖通过 NLPR3 炎性小体信号诱导视网膜小胶质细胞发生细胞焦亡。
Arq Bras Oftalmol. 2021 Jan-Feb;84(1):67-73. doi: 10.5935/0004-2749.20210010.
6
Inflammasome biology, molecular pathology and therapeutic implications.炎症小体生物学、分子病理学及其治疗意义。
Pharmacol Ther. 2018 Jul;187:133-149. doi: 10.1016/j.pharmthera.2018.02.011. Epub 2018 Feb 18.
7
Posttranslational Regulation of the NLR Family Pyrin Domain-Containing 3 Inflammasome.NLR 家族富含吡咯烷二硫化物结构域的蛋白 3 炎性小体的翻译后调控。
Front Immunol. 2018 May 18;9:1054. doi: 10.3389/fimmu.2018.01054. eCollection 2018.
8
You had me at PELO: a "Ribosome Rescuer" induces NLR inflammasome assembly.PELO就让我心动了：一种“核糖体拯救者”诱导NLR炎性小体组装。
Cell Mol Immunol. 2024 Jan;21(1):1-2. doi: 10.1038/s41423-023-01059-0. Epub 2023 Jun 27.
9
Impact of human monocyte and macrophage polarization on NLR expression and NLRP3 inflammasome activation.人类单核细胞和巨噬细胞极化对NLR表达及NLRP3炎性小体激活的影响
PLoS One. 2017 Apr 12;12(4):e0175336. doi: 10.1371/journal.pone.0175336. eCollection 2017.
10
Activation of NLRP3 Inflammasome and Onset of Alzheimer's Disease.NLRP3 炎性小体的激活与阿尔茨海默病的发病。
Front Immunol. 2021 Jul 26;12:701282. doi: 10.3389/fimmu.2021.701282. eCollection 2021.
引用本文的文献
1
Elevated apolipoprotein C3 heightens atherosclerosis risk by mediating arterial accumulation of free cholesterol and local inflammation in diabetes.载脂蛋白C3升高通过介导糖尿病患者动脉中游离胆固醇的蓄积和局部炎症反应，增加动脉粥样硬化风险。
Res Sq. 2025 Jul 16:rs.3.rs-6979508. doi: 10.21203/rs.3.rs-6979508/v1.
2
Foamy monocytes and atherogenesis in mice with combined hyperlipidemia and effects of antisense knockdown of apoCIII.合并高脂血症小鼠中的泡沫单核细胞与动脉粥样硬化形成及载脂蛋白CIII反义敲低的作用
J Lipid Res. 2025 Apr;66(4):100763. doi: 10.1016/j.jlr.2025.100763. Epub 2025 Feb 21.
3
Triglyceride-independent associations between circulating levels of apolipoprotein C-III and biomarkers of inflammation.载脂蛋白C-III循环水平与炎症生物标志物之间的非甘油三酯依赖性关联。
Cardiovasc Diabetol. 2025 Jan 8;24(1):9. doi: 10.1186/s12933-024-02553-z.
4
Type I IFN induces long-chain acyl-CoA synthetase 1 to generate a phosphatidic acid reservoir for lipotoxic saturated fatty acids.I型干扰素诱导长链脂酰辅酶A合成酶1生成用于储存脂毒性饱和脂肪酸的磷脂酸库。
J Lipid Res. 2025 Jan;66(1):100730. doi: 10.1016/j.jlr.2024.100730. Epub 2024 Dec 14.
5
Subclassification of obesity for precision prediction of cardiometabolic diseases.肥胖的亚分类用于心血管代谢疾病的精准预测。
Nat Med. 2025 Feb;31(2):534-543. doi: 10.1038/s41591-024-03299-7. Epub 2024 Oct 24.
6
Decreased Serum Apolipoprotein CIII in the Acute Phase of Kawasaki Disease.川崎病急性期血清载脂蛋白CIII降低。
Pediatr Cardiol. 2025 Jun;46(5):1282-1288. doi: 10.1007/s00246-024-03546-1. Epub 2024 Jul 2.
7
Elevated apolipoprotein C3 augments diabetic kidney disease and associated atherosclerosis in type 2 diabetes.载脂蛋白 C3 升高加剧 2 型糖尿病患者的肾脏疾病和相关动脉粥样硬化。
JCI Insight. 2024 May 14;9(12):e177268. doi: 10.1172/jci.insight.177268.
8
Apolipoprotein C3: form begets function.载脂蛋白C3：形态决定功能。
J Lipid Res. 2024 Jan;65(1):100475. doi: 10.1016/j.jlr.2023.100475. Epub 2023 Nov 14.
9
Disturbed lipid profile in common variable immunodeficiency - a pathogenic loop of inflammation and metabolic disturbances.常见可变免疫缺陷中的脂质谱紊乱 - 炎症和代谢紊乱的致病循环。
Front Immunol. 2023 Jul 20;14:1199727. doi: 10.3389/fimmu.2023.1199727. eCollection 2023.
10
A Current Update on the Role of HDL-Based Nanomedicine in Targeting Macrophages in Cardiovascular Disease.基于高密度脂蛋白的纳米药物在心血管疾病中靶向巨噬细胞作用的最新进展
Pharmaceutics. 2023 May 15;15(5):1504. doi: 10.3390/pharmaceutics15051504.
本文引用的文献
1
Unbiased spatial proteomics with single-cell resolution in tissues.无偏置空间蛋白质组学在组织中的单细胞分辨率。
Mol Cell. 2022 Jun 16;82(12):2335-2349. doi: 10.1016/j.molcel.2022.05.022.
2
Mapping cell types across human tissues.绘制人类组织中的细胞类型图谱。
Science. 2022 May 13;376(6594):695-696. doi: 10.1126/science.abq2116. Epub 2022 May 12.
3
Pulmonary surfactant protein B carried by HDL predicts incident CVD in patients with type 1 diabetes.高密度脂蛋白携带的肺表面活性物质蛋白B可预测1型糖尿病患者发生心血管疾病的风险。
J Lipid Res. 2022 Apr;63(4):100196. doi: 10.1016/j.jlr.2022.100196. Epub 2022 Mar 14.
4
Apolipoprotein C-III predicts cardiovascular events and mortality in individuals with type 1 diabetes and albuminuria.载脂蛋白 C-III 可预测伴有白蛋白尿的 1 型糖尿病患者的心血管事件和死亡。
J Intern Med. 2022 Mar;291(3):338-349. doi: 10.1111/joim.13412. Epub 2021 Nov 24.
5
Computationally efficient whole-genome regression for quantitative and binary traits.计算效率高的全基因组回归分析用于定量和二项性状。
Nat Genet. 2021 Jul;53(7):1097-1103. doi: 10.1038/s41588-021-00870-7. Epub 2021 May 20.
6
Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program.美国国立卫生研究院生物医学高级研究与发展局（NHLBI）TOPMed 项目中对 53831 个不同基因组进行测序。
Nature. 2021 Feb;590(7845):290-299. doi: 10.1038/s41586-021-03205-y. Epub 2021 Feb 10.
7
ApoC-III is a novel inducer of calcification in human aortic valves.载脂蛋白 C-III 是人类主动脉瓣钙化的新型诱导剂。
J Biol Chem. 2021 Jan-Jun;296:100193. doi: 10.1074/jbc.RA120.015700. Epub 2021 Jan 6.
8
High Concentration of Medium-Sized HDL Particles and Enrichment in HDL Paraoxonase 1 Associate With Protection From Vascular Complications in People With Long-standing Type 1 Diabetes.大颗粒高密度脂蛋白浓度升高及高密度脂蛋白对氧磷酶 1 含量增加与长期 1 型糖尿病患者血管并发症的保护相关。
Diabetes Care. 2020 Jan;43(1):178-186. doi: 10.2337/dc19-0772. Epub 2019 Oct 9.
9
Increased apolipoprotein C3 drives cardiovascular risk in type 1 diabetes.载脂蛋白 C3 升高可增加 1 型糖尿病患者的心血管风险。
J Clin Invest. 2019 Jul 11;129(10):4165-4179. doi: 10.1172/JCI127308.
10
Serum apolipoproteins and apolipoprotein-defined lipoprotein subclasses: a hypothesis-generating prospective study of cardiovascular events in T1D.血清载脂蛋白和载脂蛋白定义的脂蛋白亚类：T1D 心血管事件的生成假说前瞻性研究。
J Lipid Res. 2019 Aug;60(8):1432-1439. doi: 10.1194/jlr.P090647. Epub 2019 Jun 15.
Zotero 插件