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载脂蛋白 C3 只有在去脂形式下才能诱导炎症小体激活。

Apolipoprotein C3 induces inflammasome activation only in its delipidated form.

机构信息

Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington Medicine Diabetes Institute, University of Washington, Seattle, WA, USA.

Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA, USA.

出版信息

Nat Immunol. 2023 Mar;24(3):408-411. doi: 10.1038/s41590-023-01423-2. Epub 2023 Feb 13.

DOI:10.1038/s41590-023-01423-2
PMID:36781985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9992333/
Abstract

Matters arising regarding the lipidation form of plasma APOC3 that induces an alternative NLRP3 activation pathway.

摘要

有关诱导替代 NLRP3 激活途径的血浆 APOC3 脂化形式的问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2981/9992333/7c74a19ff419/nihms-1867745-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2981/9992333/96d2ff384f6c/nihms-1867745-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2981/9992333/5b4420845def/nihms-1867745-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2981/9992333/ad34ebe7415f/nihms-1867745-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2981/9992333/7c74a19ff419/nihms-1867745-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2981/9992333/96d2ff384f6c/nihms-1867745-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2981/9992333/5b4420845def/nihms-1867745-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2981/9992333/ad34ebe7415f/nihms-1867745-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2981/9992333/7c74a19ff419/nihms-1867745-f0002.jpg

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