Ryffel G U
Mol Cell Endocrinol. 1978 Dec;12(3):237-46. doi: 10.1016/0303-7207(78)90082-5.
The estrogen-induced synthesis of vitellogenin in the frog Xenopus and the chicken is an attractive system for investigating the molecular events leading to the activation of a specific gene. In this review article the events occurring at the level of the protein and mRNA in the cytoplasm are discussed. The available data show that the induction of vitellogenin synthesis is due to the accumulation of the corresponding vitellogenin mRNA in the cytoplasm. This suggests that transcriptional or posttranscriptional events in the nucleus are activated by the hormone. The few experiments investigating the processes in the nuclear compartment are reviewed.
雌激素诱导非洲爪蟾和鸡体内卵黄蛋白原的合成，是研究导致特定基因激活的分子事件的一个有吸引力的系统。在这篇综述文章中，我们讨论了细胞质中蛋白质和mRNA水平上发生的事件。现有数据表明，卵黄蛋白原合成的诱导是由于相应的卵黄蛋白原mRNA在细胞质中积累所致。这表明细胞核中的转录或转录后事件被激素激活。本文还综述了少数关于核区室中这些过程的实验。
