Key Lab of Health Technology Assessment of Ministry of Health, School of Public Health, Fudan University, 130 Dong-An Road, Shanghai, 200032, China.
The People's Hospital of Pingyang County, Wenzhou, 325400, Zhejiang, China.
Sci Rep. 2023 Feb 14;13(1):2627. doi: 10.1038/s41598-023-28254-3.
This study aims to investigate the association between maternal blood parameters and the risk of neonatal pathological jaundice. A retrospective case-control study of 1309 newborns and their mothers from 2019 to 2020 in a single-center tertiary hospital. All mothers received a complete routine blood test prior to delivery, and outcome was neonatal pathological jaundice. We performed stepwise logistic regression modeling to identify maternal blood factors associated with neonatal pathological jaundice. 258 neonates (19.71%) were diagnosed with pathological jaundice. Logistic regression results showed that the odds ratio for pathological jaundice in neonates of mothers with high white blood cell (WBC) count was 1.512 (95% CI 1.145-1.998; P = 0.004). Besides, neonates whose mothers had a high mean corpuscular volume (MCV) during pregnancy doubled the odds of developing pathological jaundice (OR = 1.967; 95% CI 1.043-3.711; P = 0.037). Among neonates, those whose mothers had high levels of WBC count and MCV were at increased risk of pathological jaundice. Regular obstetric examinations and routine blood tests are essential to initiate adapted care.
本研究旨在探讨产妇血液参数与新生儿病理性黄疸风险之间的关联。这是一项回顾性病例对照研究，纳入了 2019 年至 2020 年在一家单中心三级医院分娩的 1309 名新生儿及其母亲。所有母亲在分娩前均接受了完整的常规血液检查，结局为新生儿病理性黄疸。我们采用逐步逻辑回归模型来确定与新生儿病理性黄疸相关的产妇血液因素。共有 258 名新生儿（19.71%）被诊断为病理性黄疸。逻辑回归结果显示，白细胞计数（WBC）高的产妇所分娩的新生儿发生病理性黄疸的比值比为 1.512（95%CI 1.145-1.998；P=0.004）。此外，妊娠期间平均红细胞体积（MCV）较高的产妇所分娩的新生儿发生病理性黄疸的几率增加了一倍（OR=1.967；95%CI 1.043-3.711；P=0.037）。在新生儿中，WBC 计数和 MCV 较高的产妇所分娩的新生儿发生病理性黄疸的风险增加。定期进行产科检查和常规血液检查对于启动适应性护理至关重要。
