Ali Tooba, Habib Ashna, Zohair Muhammad, Aman Lubna
Dow University of Health Sciences, Karachi, Pakistan.
Department of Pediatric Nephrology, National Institute of Child Health, Karachi, Sindh, Pakistan.
J Pediatr Endocrinol Metab. 2023 Feb 16;36(4):414-417. doi: 10.1515/jpem-2022-0415. Print 2023 Apr 25.
Betamethasone causing iatrogenic Cushing's syndrome (CS) in infants are rarely reported.
In this case report, there were severe signs of CS, such as considerable weight acceleration and concurrent height deceleration, hirsutism and ecchymosis of the face, and buffalo pad, which are often found in adults. Clobetasol propionate, diflucortolone valerate, and dexamethasone nasal sprays were used in the majority of previously reported cases of corticosteroid abuse, whereas this is the first case of CS in an infant as a result of the use of betamethasone cream, also known as betnesol, which is frequently used by mothers in developing countries as a treatment for rashes. In this instance, a severe medication interaction caused by systemic betamethasone cream buildup led to the creation of CS. For the professionals, these patients are a challenge because of drug use without prescription.
Topical corticosteroid usage puts infants at risk for CS. Because of excessive betamethasone treatment in this child with diaper dermatitis, he acquired CS. It is said to draw attention to the risks of self-medication in developing nations.
婴儿因倍他米松导致医源性库欣综合征(CS)的报道很少。
在本病例报告中,出现了严重的CS体征,如体重显著加速增长同时身高减速、多毛症、面部瘀斑以及常在成人中出现的水牛背。在大多数先前报道的皮质类固醇滥用病例中使用的是丙酸氯倍他索、戊酸倍氟米松和地塞米松鼻喷雾剂,而这是首例因使用倍他米松乳膏(也称为倍诺松)导致婴儿患CS的病例,在发展中国家母亲们常将其用于治疗皮疹。在这种情况下,全身倍他米松乳膏蓄积导致严重的药物相互作用,进而引发了CS。对于专业人员来说,这些患者因无处方用药而成为一个挑战。
局部使用皮质类固醇会使婴儿面临患CS的风险。由于对该患尿布皮炎的儿童过度使用倍他米松治疗,他患上了CS。据说这引起了人们对发展中国家自我用药风险的关注。