Section of Endocrinology and Metabolism, Deming Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Tulane Center of Excellence in Sex-Based Biology & Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA.
J Diabetes. 2023 Feb;15(2):185-189. doi: 10.1111/1753-0407.13358. Epub 2023 Feb 14.
Fasting glucose‐defined prediabetes and undiagnosed diabetes based on the American Diabetes Association criteria were associated with a greater risk of coronary heart disease, stroke, and composite atherosclerotic cardiovascular disease in women. In contrast, oral glucose tolerance‐defined prediabetes and undiagnosed diabetes were associated with a greater risk of all cardiovascular outcomes in men. Intermediate A1c was associated with a more pronounced effect on the risk of coronary heart disease and stroke in women, whereas the above diagnostic level of A1c was associated with a higher magnitude of coronary heart risk in undiagnosed men but a higher magnitude of stroke risk in undiagnosed women.
禁食血糖定义的糖尿病前期和美国糖尿病协会标准定义的未诊断糖尿病与女性冠心病、中风和复合动脉粥样硬化性心血管疾病的风险增加相关。相比之下，口服葡萄糖耐量定义的糖尿病前期和未诊断糖尿病与男性所有心血管结局的风险增加相关。中间糖化血红蛋白与女性冠心病和中风风险的影响更为显著，而上述糖化血红蛋白诊断水平与未诊断男性的冠心病风险增加幅度更大，但与未诊断女性的中风风险增加幅度更大。
