Meyer Oanh L, Besser Lilah, Tobias Michele, George Kristen M, Gavett Brandon, Farias Sarah Tomaszewski, Bhagat Nishi, Pham My Le, Chrisphonte Stephanie, Whitmer Rachel A
Department of Neurology University of California Davis School of Medicine Sacramento California USA.
Department of Neurology University of Miami Miller School of Medicine Boca Raton Florida USA.
Alzheimers Dement (Amst). 2023 Feb 8;15(1):e12401. doi: 10.1002/dad2.12401. eCollection 2023 Jan-Mar.
Few longitudinal studies have examined the joint impact of neighborhood segregation and neighborhood socioeconomic status (NSES) in cognitive decline over time.
This study included non-Hispanic White (NHW, = 209) and Black participants ( = 118) whose cognition was evaluated as part of an ongoing longitudinal study. Four distinct categories of segregation and NSES were evaluated for their association with cognitive outcomes (episodic memory, semantic memory, executive function, and spatial ability) using race-specific mixed-effects models.
Compared to Black participants living in higher segregation-lower NSES areas, Black participants living in lower segregation-lower NSES areas or higher segregation-higher NSES areas experienced slower decline in episodic memory over time. Compared to NHW participants living in higher segregation-lower NSES areas, NHWs living in lower segregation-higher NSES areas experienced faster decline in spatial ability.
Segregation and NSES are differentially associated with cognition depending on participant race. Further research is needed to replicate study results.
很少有纵向研究考察邻里隔离和邻里社会经济地位（NSES）随时间推移对认知衰退的联合影响。
本研究纳入了非西班牙裔白人（NHW，n = 209）和黑人参与者（n = 118），他们的认知作为一项正在进行的纵向研究的一部分进行了评估。使用种族特异性混合效应模型评估了四种不同类别的隔离和NSES与认知结果（情景记忆、语义记忆、执行功能和空间能力）之间的关联。
与生活在高隔离 - 低NSES地区的黑人参与者相比，生活在低隔离 - 低NSES地区或高隔离 - 高NSES地区的黑人参与者随着时间的推移情景记忆衰退较慢。与生活在高隔离 - 低NSES地区的NHW参与者相比，生活在低隔离 - 高NSES地区的NHW参与者空间能力衰退较快。
隔离和NSES与认知的关联因参与者种族而异。需要进一步的研究来重复研究结果。
