Merkin Sharon Stein, Karlamangla Arun, Roux Ana Diez, Shrager Sandi, Watson Karol, Seeman Teresa
Division of Geriatrics, Geffen School of Medicine at UCLA, 10945 Le Conte Avenue, Suite 2339, Los Angeles, CA, 90095-1687, USA.
Drexel University Dornsife School of Public Health, 3215 Market Street, Nesbitt Hall 2nd Floor, Room 255, Philadelphia, PA, 19104, USA.
SSM Popul Health. 2020 Jul 23;11:100634. doi: 10.1016/j.ssmph.2020.100634. eCollection 2020 Aug.
To determine the association between neighborhood socioeconomic status (NSES) and cardio-metabolic risk and whether this relationship differs by race/ethnicity.
Participants in the Multi-Ethnic Study of Atherosclerosis (n = 5750), ages 45-84 years, from 6 US counties, including 5 examinations from 2000 to 2012. We calculated a modified allostatic load (AL) index, indicating cardio-metabolic risk. NSES score included census-derived measures at census tract of residence. Mixed effects growth curve models were used to assess linear and non-linear associations between NSES and AL at baseline and over time.
Higher NSES was associated with lower AL across race/ethnic groups; considering NSES quintiles, significant associations were found only for the highest NSES quintiles (difference of -0.86 and -1.15 for white and Hispanic participants) vs. the lowest. We found no significant association between NSES and change in AL over time.
Our findings suggest that the relationship between NSES and AL reflects the health benefits of living in the most advantaged neighborhoods.
Understanding the impact of higher NSES on health effects may help identify interventions to effectively target high risk neighborhoods.
确定邻里社会经济地位（NSES）与心血管代谢风险之间的关联，以及这种关系是否因种族/族裔而异。
来自美国6个县的动脉粥样硬化多族裔研究参与者（n = 5750），年龄在45 - 84岁之间，包括2000年至2012年的5次检查。我们计算了一个改良的应激负荷（AL）指数，以表明心血管代谢风险。NSES得分包括居住普查区基于人口普查得出的指标。使用混合效应生长曲线模型评估基线时以及随时间推移NSES与AL之间的线性和非线性关联。
在所有种族/族裔群体中，较高的NSES与较低的AL相关；考虑NSES五分位数时，仅在最高NSES五分位数（白人和西班牙裔参与者分别为 -0.86和 -1.15的差异）与最低五分位数之间发现了显著关联。我们发现NSES与随时间变化的AL之间没有显著关联。
我们的研究结果表明，NSES与AL之间的关系反映了生活在最优越社区的健康益处。
了解较高的NSES对健康影响的作用可能有助于确定有效针对高风险社区的干预措施。
