Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, 11794, USA.
St. Francis Hospital, Roslyn, NY, 11576, USA.
Med Biol Eng Comput. 2023 Jun;61(6):1533-1548. doi: 10.1007/s11517-023-02791-5. Epub 2023 Feb 15.
Biomechanics plays a critical role in coronary artery disease development. FSI simulation is commonly used to understand the hemodynamics and mechanical environment associated with atherosclerosis pathology. To provide a comprehensive characterization of patient-specific coronary biomechanics, an analysis of FSI simulation in the spatial and temporal domains was performed. In the current study, a three-dimensional FSI model of the LAD coronary artery was built based on a patient-specific geometry using COMSOL Multiphysics. The effect of myocardial bridging was simulated. Wall shear stress and its derivatives including time-averaged wall shear stress, wall shear stress gradient, and OSI were calculated across the cardiac cycle in multiple locations. Arterial wall strain (radial, circumferential, and longitudinal) and von Mises stress were calculated. To assess perfusion, vFFR was calculated. The results demonstrated the FSI model could identify regional and transient differences in biomechanical parameters within the coronary artery. The addition of myocardial bridging caused a notable change in von Mises stress and an increase in arterial strain during systole. The analysis performed in this manner takes greater advantage of the information provided in the space and time domains and can potentially assist clinical evaluation.
生物力学在冠状动脉疾病的发展中起着至关重要的作用。FSI 模拟常用于了解与动脉粥样硬化病理学相关的血液动力学和力学环境。为了全面描述患者特定的冠状动脉生物力学特性，对 FSI 模拟在空间和时间域中的特性进行了分析。在本研究中，基于特定于患者的几何形状，使用 COMSOL Multiphysics 构建了左前降支冠状动脉的三维 FSI 模型。模拟了心肌桥的影响。计算了在多个位置的心动周期内的壁面剪切应力及其导数，包括时均壁面剪切应力、壁面剪切应力梯度和 OSI。计算了动脉壁应变（径向、周向和纵向）和 von Mises 应力。为了评估灌注，计算了 vFFR。结果表明，FSI 模型能够识别冠状动脉内生物力学参数的区域和瞬态差异。心肌桥的加入导致在收缩期 von Mises 应力显著增加和动脉应变增加。以这种方式进行的分析可以更好地利用空间和时间域提供的信息，并有可能辅助临床评估。
