Immunology Service, Professor Edgard Santos University Hospital Complex, Federal University of Bahia, Salvador, Bahia, Brazil.
Post-Graduate Course in Health Sciences, Federal University of Bahia Medical School. Salvador, Bahia, Brazil.
PLoS Negl Trop Dis. 2023 Feb 15;17(2):e0011064. doi: 10.1371/journal.pntd.0011064. eCollection 2023 Feb.
Dogs living in areas of Leishmania (Viannia) braziliensis transmission may present canine tegumentary leishmaniasis (CTL) characterized by cutaneous or muzzle ulcers as well as asymptomatic L. braziliensis infection. It is not clear if dogs participate in the transmission chain of L. braziliensis to humans. However, dogs may remain with chronic ulcers for a long time, and as there are no public policies about CTL, these animals die or are sacrificed. Here we compare the efficacy of intralesional meglumine antimoniate with intralesional 0.9% NaCl solution in CTL treatment. This randomized control study included 32 dogs with cutaneous or muzzle lesions who had L. braziliensis DNA detected by PCR in tissue biopsied. Group one received 5ml of intralesional Glucantime, and group two received 5ml 0.9% NaCl solution, both applied in the four cardinal points on days 0, 15, and 30. Cure was defined as complete healing of the ulcers in the absence of raised borders on day 90. There was no difference in animals' demographic and clinical features in the two groups (p >.05). While at the endpoint, the cure rate was 87.5% in the group test, and in those who received 0.9 NaCl the cure rate was only 12.5%. As important as the high cure rate, the healing time was faster in dogs treated with antimony than in those treated with saline (p < .001). Intralesional meglumine antimoniate is effective in the treatment of dogs with L. braziliensis infection and accelerates the healing time of CTL.
生活在莱什曼原虫（Viannia）巴西利ensis 传播区域的狗可能患有犬皮肤利什曼病（CTL），其特征是皮肤或口鼻溃疡以及无症状的巴西利ensis 感染。目前尚不清楚狗是否参与了巴西利ensis 向人类的传播链。然而，狗可能会长期患有慢性溃疡，而且由于没有针对 CTL 的公共政策，这些动物会死亡或被牺牲。在这里，我们比较了病灶内葡甲胺锑和病灶内 0.9%生理盐水溶液在 CTL 治疗中的疗效。这项随机对照研究纳入了 32 只患有皮肤或口鼻病变的狗，这些狗的组织活检中通过 PCR 检测到了巴西利ensis DNA。一组接受 5ml 病灶内 Glucantime，另一组接受 5ml 0.9%生理盐水溶液，均在第 0、15 和 30 天在四个方位点注射。治愈定义为第 90 天溃疡完全愈合且无隆起边缘。两组动物的人口统计学和临床特征无差异（p >.05）。虽然在终点时，实验组的治愈率为 87.5%，而接受 0.9%生理盐水的治愈率仅为 12.5%。除了高治愈率外，接受锑治疗的狗的愈合时间比接受生理盐水治疗的狗更快（p <.001）。病灶内葡甲胺锑对巴西利ensis 感染的狗有效，并加速了 CTL 的愈合时间。
