Weiss L M, Strickler J G, Medeiros L J, Gerdes J, Stein H, Warnke R A
Department of Pathology, Stanford University, California.
Hum Pathol. 1987 Nov;18(11):1155-9. doi: 10.1016/s0046-8177(87)80384-2.
The Ki-67 antibody, a monoclonal antibody that reacts with nuclei in actively proliferating cells, was used in an immunohistochemical study to assess the growth fractions of non-Hodgkin's lymphomas and related disorders. The lowest proliferative indices were found in small lymphocytic lymphoma/chronic lymphocytic leukemia and intermediate lymphocytic/mantle zone lymphoma. An intermediate proliferative index was seen in the follicular lymphomas and diffuse small cleaved cell and diffuse mixed cell lymphomas. A high index was seen in the diffuse large cell lymphoma and lymphoblastic lymphoma. The highest and most consistent proliferative index was seen in small noncleaved cell lymphoma. Cases of reactive follicular hyperplasia had a significantly higher proliferative index than those of follicular lymphoma. We conclude that the Ki-67 antibody has great utility in providing an estimate of the proliferative rate of non-Hodgkin's lymphomas. Prospective studies may show this information to have prognostic value independent of histologic classification.
Ki-67抗体是一种与活跃增殖细胞的细胞核发生反应的单克隆抗体，在一项免疫组织化学研究中用于评估非霍奇金淋巴瘤及相关疾病的生长分数。在小淋巴细胞淋巴瘤/慢性淋巴细胞白血病以及中等淋巴细胞/套细胞淋巴瘤中发现最低的增殖指数。在滤泡性淋巴瘤、弥漫性小裂细胞淋巴瘤和弥漫性混合细胞淋巴瘤中观察到中等增殖指数。在弥漫性大细胞淋巴瘤和淋巴母细胞淋巴瘤中观察到高指数。在小无裂细胞淋巴瘤中观察到最高且最一致的增殖指数。反应性滤泡增生病例的增殖指数明显高于滤泡性淋巴瘤病例。我们得出结论，Ki-67抗体在估计非霍奇金淋巴瘤的增殖率方面具有很大用途。前瞻性研究可能表明该信息具有独立于组织学分类的预后价值。
