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副溶血性弧菌流行病学与发病机制:新兴食源性病原体的新见解。

Vibrio parahaemolyticus Epidemiology and Pathogenesis: Novel Insights on an Emerging Foodborne Pathogen.

机构信息

Instituto Nacional de Salud, Lima, Peru.

Escuela Profesional de Medicina Humana, Universidad Privada San Juan Bautista, Lima, Peru.

出版信息

Adv Exp Med Biol. 2023;1404:233-251. doi: 10.1007/978-3-031-22997-8_12.

Abstract

The epidemiological dynamics of V. parahaemolyticus´ infections have been characterized by the abrupt appearance of outbreaks in remote areas where these diseases had not been previously detected, without knowing the routes of entry of the pathogens in the new area. However, there are recent studies that show the link between the appearance of epidemic outbreaks of Vibrio and environmental factors such as oceanic transport of warm waters, which has provided a possible mechanism for the dispersion of Vibrio diseases globally. Despite this evidence, there is little information on the possible routes of entry and transport of infectious agents from endemic countries to the entire world. In this sense, the recent advances in genomic sequencing tools are making it possible to infer possible biogeographical patterns of diverse pathogens with relevance in public health like V. parahaemolyticus. In this chapter, we will address several general aspects about V. parahaemolyticus, including their microbiological and genetic detection, main virulence factors, and the epidemiology of genotypes involved in foodborne outbreaks globally.

摘要

副溶血性弧菌感染的流行病学动态的特点是,在以前没有检测到这些疾病的偏远地区突然出现暴发,而不知道病原体在新地区的进入途径。然而,最近的一些研究表明,弧菌的流行暴发与海洋温暖水流的运输等环境因素之间存在联系,这为弧菌疾病在全球的传播提供了一个可能的机制。尽管有这些证据,但关于从流行国家向全世界输入传染性病原体的可能途径和运输方式的信息却很少。在这方面,基因组测序工具的最新进展使得推断与副溶血性弧菌等与公共卫生相关的不同病原体的可能生物地理模式成为可能。在本章中,我们将讨论有关副溶血性弧菌的几个一般方面,包括其微生物学和遗传学检测、主要毒力因子以及与食源性暴发相关的基因型的全球流行病学。

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