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斯瓦尔帕霉素,一种新型大环内酯类抗生素。I. 产生菌的分类学、发酵、分离及生物活性

Swalpamycin, a new macrolide antibiotic. I. Taxonomy of the producing organism, fermentation, isolation and biological activity.

作者信息

Franco C M, Gandhi J N, Chatterjee S, Ganguli B N

机构信息

Microbiology Department, Research Centre, Hoechst India Limited, Bombay.

出版信息

J Antibiot (Tokyo). 1987 Oct;40(10):1361-7. doi: 10.7164/antibiotics.40.1361.

DOI:10.7164/antibiotics.40.1361
PMID:3680001
Abstract

A new macrolide antibiotic, swalpamycin, has been isolated from the culture broth of Streptomyces sp. Y-84,30967. Taxonomically the producing organism most closely resembles Streptomyces anandii and has therefore been named S. anandii subsp. swalpus. Swalpamycin is a neutral 16-membered macrolide active against Gram-positive bacteria including erythromycin-resistant strains.

摘要

一种新的大环内酯类抗生素——斯瓦尔帕霉素,已从链霉菌属菌株Y - 8430967的培养液中分离出来。从分类学角度来看,产生该抗生素的生物体与阿南德链霉菌最为相似,因此被命名为阿南德链霉菌斯瓦尔帕亚种。斯瓦尔帕霉素是一种中性的16元大环内酯类抗生素,对革兰氏阳性菌具有活性,包括耐红霉素菌株。

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