SF2446，新型苯并[a]萘并蒽醌类抗生素。I. 产生菌的分类学与发酵、抗生素的分离与特性鉴定
SF2446, new benzo[a]naphthacene quinone antibiotics. I. Taxonomy and fermentation of the producing strain, isolation and characterization of antibiotics.
作者信息
Takeda U, Okada T, Takagi M, Gomi S, Itoh J, Sezaki M, Ito M, Miyadoh S, Shomura T
机构信息
Pharmaceutical Research Laboratories, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
出版信息
J Antibiot (Tokyo). 1988 Apr;41(4):417-24. doi: 10.7164/antibiotics.41.417.
New antibiotics SF2446A1, A2, A3, B1 and B2 have been isolated from the culture of Streptomyces sp. SF2446 and antibiotic SF2446B3 has been obtained by methanolysis of SF2446B1 or B2. SF2446A1, A2 and B1 showed strong inhibitory activities against mycoplasmas and Gram-positive bacteria. Empirical molecular formulae of antibiotics SF2446-A1, A2, A3, B1, B2 and B3 were determined to be C34H35NO15, C26H21NO11, C34H35NO14, C34H35NO14 and C26H21NO10, respectively.
新型抗生素SF2446A1、A2、A3、B1和B2是从链霉菌属SF2446的培养物中分离得到的，抗生素SF2446B3是通过对SF2446B1或B2进行甲醇解反应获得的。SF2446A1、A2和B1对支原体和革兰氏阳性菌表现出强烈的抑制活性。抗生素SF2446 - A1、A2、A3、B1、B2和B3的经验分子式分别确定为C34H35NO15、C26H21NO11、C34H35NO14、C34H35NO14和C26H21NO10。
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