一种新型抗生素，索布霉素。分类学、发酵、分离以及物理化学和生物学特性。

A novel antibiotic, sohbumycin. Taxonomy, fermentation, isolation and physico-chemical and biological characteristics.

作者信息

Umezawa I, Tronquet C, Funayama S, Okada K, Komiyama K

出版信息

J Antibiot (Tokyo). 1985 Aug;38(8):967-71. doi: 10.7164/antibiotics.38.967.

DOI:10.7164/antibiotics.38.967

Abstract

A new antibiotic sohbumycin, was isolated from the culture broth of Streptomyces sp. No. 82-85. It appeared to belong to the peptide lactone type of antibiotics from physico-chemical studies and has an empirical formula of C31H47N8O10Cl. In in vitro studies, the antibiotic was found to possess potent cytocidal activity against HeLa S3 cells and antimicrobial activities against Gram-positive bacteria with MIC values about 0.3-0.6 microgram/ml, but showed no activity on the Gram-negative bacteria, yeast and fungi tested.

摘要

一种新的抗生素索布霉素，是从链霉菌属82 - 85号菌株的培养液中分离出来的。通过物理化学研究，它似乎属于肽内酯类抗生素，其经验式为C31H47N8O10Cl。在体外研究中，发现该抗生素对HeLa S3细胞具有强大的杀细胞活性，对革兰氏阳性菌具有抗菌活性，MIC值约为0.3 - 0.6微克/毫升，但对所测试的革兰氏阴性菌、酵母和真菌没有活性。