Angolkar Mohit, Paramshetti Sharanya, Halagali Praveen, Jain Vikas, Patil Amit B, Somanna Preethi
Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, SS Nagar, Mysuru, 570015, India.
Ther Deliv. 2023 Feb 21. doi: 10.4155/tde-2022-0035.
Nanotechnological advancements over the past few years have led to the development of newer treatment strategies in brain cancer therapy which leads to the establishment of nano oncology. Nanostructures with high specificity, are best suitable to penetrate the blood-brain barrier (BBB). Their desired physicochemical properties, such as small sizes, shape, higher surface area to volume ratio, distinctive structural features, and the possibility to attach various substances on their surface transform them into potential transport carriers able to cross various cellular and tissue barriers, including the BBB. The review emphasizes nanotechnology-based treatment strategies for the exploration of brain tumors and highlights the current progress of different nanomaterials for the effective delivery of drugs for brain tumor therapy.
过去几年里，纳米技术的进步推动了脑癌治疗新策略的发展，进而催生了纳米肿瘤学。具有高特异性的纳米结构最适合穿透血脑屏障（BBB）。它们理想的物理化学性质，如小尺寸、形状、高表面积与体积比、独特的结构特征以及在其表面附着各种物质的可能性，将它们转变为能够跨越包括血脑屏障在内的各种细胞和组织屏障的潜在转运载体。这篇综述着重介绍了基于纳米技术的脑肿瘤治疗策略，并突出了不同纳米材料在有效递送用于脑肿瘤治疗的药物方面的当前进展。
