State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Expert Rev Clin Immunol. 2023 Apr;19(4):405-415. doi: 10.1080/1744666X.2023.2182291. Epub 2023 Feb 28.
Innate immunity serves as the frontline to combat invading pathogens. Oral microbiota is the total collection of microorganisms colonized within the oral cavity. By recognizing the resident microorganisms through pattern recognition receptors, innate immunity is capable of interacting with oral microbiota and maintaining homeostasis. Dysregulation of interaction may lead to the pathogenesis of several oral diseases. Decoding the crosstalk between oral microbiota and innate immunity may be contributory to developing novel therapies for preventing and treating oral diseases.
This article reviewed pattern recognition receptors in the recognition of oral microbiota, the reciprocal interaction between innate immunity and oral microbiota, and discussed how the dysregulation of this relationship leads to the pathogenesis and development of oral diseases.
Many studies have been conducted to illustrate the relationship between oral microbiota and innate immunity and its role in the occurrence of different oral diseases. The impact and mechanisms of innate immune cells on oral microbiota and the mechanisms of dysbiotic microbiota in altering innate immunity are still needed to be investigated. Altering the oral microbiota might be a possible solution for treating and preventing oral diseases.
先天免疫是抵御入侵病原体的第一道防线。口腔微生物群是定植于口腔内的微生物总体。先天免疫通过模式识别受体识别常驻微生物，从而与口腔微生物群相互作用并维持体内平衡。相互作用的失调可能导致多种口腔疾病的发病机制。解析口腔微生物群与先天免疫之间的相互作用可能有助于开发预防和治疗口腔疾病的新疗法。
本文综述了口腔微生物群识别中的模式识别受体、先天免疫与口腔微生物群的相互作用，并讨论了这种关系失调如何导致口腔疾病的发病机制和发展。
许多研究已经阐明了口腔微生物群和先天免疫之间的关系及其在不同口腔疾病发生中的作用。仍需要研究先天免疫细胞对口腔微生物群的影响及其机制，以及失调的微生物群改变先天免疫的机制。改变口腔微生物群可能是治疗和预防口腔疾病的一种可行方法。
