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评估用于小移动目标的立体定向容积旋转调强放疗(VMAT)肺治疗计划。

Evaluation of stereotactic VMAT lung treatment plans for small moving targets.

机构信息

Institut de Cancérologie de l'Ouest, Angers, France; CEA, List, Laboratoire National Henri Becquerel (LNE-LNHB), Palaiseau, France.

Institut de Cancérologie de l'Ouest, Angers, France.

出版信息

Phys Med. 2023 Mar;107:102547. doi: 10.1016/j.ejmp.2023.102547. Epub 2023 Feb 17.

Abstract

PURPOSE

The aim of this study is to perform patient quality controls and end-to-end tests for stereotactic VMAT lung treatment plans and to investigate the influence of various parameters on the results.

METHOD

18 plans were defined by an experimental design methodology to cover a large variety of stereotactic VMAT lung treatments including different doses per fraction, target diameters, target movements and respiratory parameters. Plans were first controlled using portal dosimetry and a homogeneous static cylindrical phantom. End-to-end tests were then performed in a dynamic respiratory thorax phantom. Measurements were conducted with ionization chamber and films. Calculations were performed with the AcurosXB and AAA algorithms in 6 FFF.

RESULTS

Portal dosimetry gave excellent gamma pass rates (greater than 97.1 %) and dose deviations between measurement and calculations in a homogeneous static phantom were smaller than 2 %. The methodology followed for comparing calculated and measured doses in a moving target was validated in static fields (largest deviation smaller than  2 %). End-to-end tests showed mean deviations of 1.9 %, 3.3 % and 6.6 % for the 3, 2 and 1 cm diameter's target respectively. Deviations increased for larger movements for the 1 cm lesion.

CONCLUSION

End-to-end tests revealed that stereotactic VMAT lung treatment plans for moving targets can be delivered within 5 % for 3 and 2 cm diameter targets and amplitudes up to 1.5 cm. The AcurosXB and AAA algorithms however tend to underestimate the dose to the target. Even with satisfactory patient quality controls like portal dosimetry, extra care should be taken for GTV lesions smaller than 2 cm.

摘要

目的

本研究旨在对立体定向 VMAT 肺部治疗计划进行患者质量控制和端到端测试,并研究各种参数对结果的影响。

方法

通过实验设计方法定义了 18 个计划,以涵盖各种立体定向 VMAT 肺部治疗方案,包括不同的分次剂量、靶直径、靶运动和呼吸参数。首先使用门控剂量测量和均匀静态圆柱体体模对计划进行控制。然后在动态呼吸胸部体模中进行端到端测试。使用电离室和胶片进行测量。使用 AcurosXB 和 AAA 算法在 6FFF 中进行计算。

结果

门控剂量测量得到了极好的伽马通过率(大于 97.1%),并且在均匀静态体模中测量和计算之间的剂量偏差小于 2%。在移动目标中比较计算和测量剂量所采用的方法在静态场中得到了验证(最大偏差小于 2%)。端到端测试显示,对于 3、2 和 1cm 直径的靶,平均偏差分别为 1.9%、3.3%和 6.6%。对于 1cm 病变,较大的运动导致偏差增加。

结论

端到端测试表明,对于移动目标的立体定向 VMAT 肺部治疗计划,可以在 3 和 2cm 直径的靶和幅度高达 1.5cm 的情况下,将剂量输送到 5%以内。然而,AcurosXB 和 AAA 算法往往低估了靶区的剂量。即使有门控剂量测量等令人满意的患者质量控制,对于小于 2cm 的 GTV 病变也应格外小心。

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