采用酶联免疫吸附测定法检测一组儿童血清中针对肺炎球菌荚膜多糖的IgG抗体。
ELISA determination of IgG antibodies to pneumococcal capsular polysaccharides in a group of children.
作者信息
Windebank K P, Faux J A, Chapel H M
机构信息
Department of Paediatrics, John Radcliffe Hospital, Oxford, U.K.
出版信息
J Immunol Methods. 1987 Nov 23;104(1-2):143-8. doi: 10.1016/0022-1759(87)90498-4.
An enzyme-linked immunosorbent assay (ELISA) was developed to measure specific IgG antibody levels to pneumococcal polysaccharide antigens in 300 children attending various hospital departments. By expressing the results as a specific binding index (SBI) of given high and low controls, good reproducibility was obtained. Serum levels of the antibodies were found to fall rapidly during the 1st year of life, plateau during the 2nd and then rise steadily, reaching adult levels by the 7th year.
开发了一种酶联免疫吸附测定法（ELISA），用于测量300名来自不同医院科室的儿童针对肺炎球菌多糖抗原的特异性IgG抗体水平。通过将结果表示为给定高、低对照的特异性结合指数（SBI），获得了良好的重现性。发现抗体的血清水平在生命的第1年迅速下降，在第2年趋于平稳，然后稳步上升，到第7年达到成人水平。
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