Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Department of Orthopedic Surgery, Civil Aviation Hospital of Shanghai, Shanghai, China.
BMC Musculoskelet Disord. 2023 Feb 21;24(1):135. doi: 10.1186/s12891-023-06244-w.
In this study, we try to investigate the effect of antibiotic bone cement in patients with infected diabetic foot ulcer (DFU).
This is a retrospective study, including fifty-two patients with infected DFU who had undergone treated between June 2019 and May 2021. Patients were divided into Polymethylmethacrylate (PMMA) group and control group. 22 patients in PMMA group received antibiotic bone cement and regular wound debridement, and 30 patients in control group received regular wound debridement. Clinical outcomes include the rate of wound healing, duration of healing, duration of wound preparation, rate of amputation, and frequency of debridement procedures.
In PMMA group, twenty-two patients (100%) had complete wound healing. In control group, twenty-eight patients (93.3%) had wound healing. Compared with control group, PMMA group had fewer frequencies of debridement procedures and shorter duration of wound healing (35.32 ± 3.77 days vs 44.37 ± 7.44 days, P < 0.001). PMMA group had five minor amputation, while control group had eight minor amputation and two major amputation. Regarding the rate of limb salvage, there was no limb lose in PMMA group and two limb losses in control group.
The application of antibiotic bone cement is an effective solution for infected DFU treatment. It can effectively decreased the frequency of debridement procedures and shorten the healing duration in patients with infected DFU.
在本研究中，我们试图探讨抗生素骨水泥在感染性糖尿病足溃疡（DFU）患者中的作用。
这是一项回顾性研究，纳入了 2019 年 6 月至 2021 年 5 月期间接受治疗的 52 例感染性 DFU 患者。患者分为聚甲基丙烯酸甲酯（PMMA）组和对照组。PMMA 组 22 例患者接受抗生素骨水泥和常规清创，对照组 30 例患者仅接受常规清创。临床结局包括伤口愈合率、愈合时间、伤口准备时间、截肢率和清创次数。
在 PMMA 组，22 例患者（100%）完全愈合。在对照组，28 例患者（93.3%）伤口愈合。与对照组相比，PMMA 组的清创次数更少，愈合时间更短（35.32±3.77 天 vs 44.37±7.44 天，P<0.001）。PMMA 组有 5 例小截肢，对照组有 8 例小截肢和 2 例大截肢。关于保肢率，PMMA 组无肢体丧失，对照组有 2 例肢体丧失。
抗生素骨水泥的应用是治疗感染性 DFU 的有效方法。它可以有效减少感染性 DFU 患者的清创次数，缩短愈合时间。
