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诺雷科帕:一个用于改进动物研究与试验的全球资源知识库。

Norecopa: A global knowledge base of resources for improving animal research and testing.

作者信息

Smith Adrian J

机构信息

Norecopa, c/o Norwegian Veterinary Institute, Ås, Norway.

出版信息

Front Vet Sci. 2023 Feb 2;10:1119923. doi: 10.3389/fvets.2023.1119923. eCollection 2023.

DOI:10.3389/fvets.2023.1119923
PMID:36816191
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9932590/
Abstract

There are good ethical, legal and scientific reasons for ensuring that our use of animals in research and testing is limited to the lowest number of animals, and that those which are used are treated as humanely as possible, while at the same time providing reliable, reproducible and translatable data which is adequately reported. Unfortunately, there is widespread evidence that there is room for improvement in all these areas. This paper describes the Norecopa website, which offers links to global resources which can be used to resolve these issues. Much of the website content is linked to the PREPARE guidelines for planning any research or testing which appears to need animals. Attention to detail on all steps of the pathway from early planning to manuscript submission should lead to better science, improved animal welfare, and fewer health and safety accidents. This will also minimize the chances of manuscript rejection due to inadequate planning, avoiding a waste of human resources and animal lives.

摘要

出于良好的伦理、法律和科学原因,我们应确保在研究和测试中对动物的使用仅限于最少数量的动物,并且对所用动物给予尽可能人道的对待,同时提供可靠、可重复且可转化的数据,并进行充分报告。不幸的是,有广泛的证据表明,在所有这些领域都有改进的空间。本文介绍了Norecopa网站,该网站提供了可用于解决这些问题的全球资源链接。网站的大部分内容都与PREPARE指南相关,该指南用于规划任何似乎需要动物的研究或测试。在从早期规划到稿件提交的整个过程中注重细节,将有助于产生更好的科学成果、改善动物福利,并减少健康和安全事故。这也将最大限度地减少因规划不足而导致稿件被拒的可能性,避免浪费人力资源和动物生命。

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本文引用的文献

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Recommendations to improve use and reporting of statistics in animal experiments.动物实验中统计学使用和报告的改进建议。
Lab Anim. 2023 Jun;57(3):224-235. doi: 10.1177/00236772221140669. Epub 2022 Dec 1.
2
Mouse background genetics in biomedical research: The devil's in the details.在生物医学研究中使用的小鼠背景遗传学:细节决定成败。
Transfusion. 2021 Oct;61(10):3017-3025. doi: 10.1111/trf.16628. Epub 2021 Sep 3.
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A manifesto for reproducible science.可重复科学宣言。
Nat Hum Behav. 2017 Jan 10;1(1):0021. doi: 10.1038/s41562-016-0021.
4
A Validated Smartphone-based Electrocardiogram Reveals Severe Bradyarrhythmias during Immobilizing Restraint in Mice of Both Sexes and Four Strains.一种经验证的基于智能手机的心电图可在两种性别和四个品系的束缚静止的小鼠中揭示严重的心动过缓。
J Am Assoc Lab Anim Sci. 2021 Mar 1;60(2):201-212. doi: 10.30802/AALAS-JAALAS-20-000069. Epub 2021 Feb 26.
5
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research.ARRIVE 指南 2.0:报告动物研究的更新指南。
PLoS Biol. 2020 Jul 14;18(7):e3000410. doi: 10.1371/journal.pbio.3000410. eCollection 2020 Jul.
6
Choice of Laboratory Rodent Diet May Confound Data Interpretation and Reproducibility.实验用啮齿动物饮食的选择可能会混淆数据解读和可重复性。
Curr Dev Nutr. 2020 Mar 9;4(4):nzaa031. doi: 10.1093/cdn/nzaa031. eCollection 2020 Apr.
7
Reproducibility and Rigor in Animal-Based Research.基于动物的研究中的可重复性和严谨性。
ILAR J. 2019 Dec 31;60(1):17-23. doi: 10.1093/ilar/ilz015.
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Experiments done in Black-6 mice: what does it mean?在 Black-6 小鼠中进行的实验:这是什么意思?
Lab Anim (NY). 2019 Jun;48(6):171-180. doi: 10.1038/s41684-019-0288-8. Epub 2019 Apr 22.
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The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments).《IMPROVE指南(缺血模型:体内实验的程序优化)》
J Cereb Blood Flow Metab. 2017 Nov;37(11):3488-3517. doi: 10.1177/0271678X17709185. Epub 2017 Aug 11.
10
PREPARE: guidelines for planning animal research and testing.《准备:动物研究与试验规划指南》
Lab Anim. 2018 Apr;52(2):135-141. doi: 10.1177/0023677217724823. Epub 2017 Aug 3.