营养干预联合肌肉锻炼对股骨骨折患者肌少症的临床疗效：一项初步随机对照试验。
Clinical Efficacy of Nutritional Intervention Combined with Muscle Exercise on Sarcopenia Patients with Femoral Fracture: A Pilot Randomized Controlled Trial.
机构信息
Department of Orthopedics, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
出版信息
Biomed Res Int. 2023 Feb 10;2023:3222686. doi: 10.1155/2023/3222686. eCollection 2023.
OBJECTIVE
To study the clinical efficacy of nutritional intervention combined with muscle exercise on sarcopenia patients with femoral fracture.
METHODS
From January 2019 to January 2021, a total of 100 sarcopenia patients with femoral fracture were included in this study and were divided into a control group (routine postoperative care) and a research group (nutritional intervention and muscle exercise), 50 cases in each group. Primary clinical outcomes included sarcopenia-related indicators and functional independence assessed by activities of daily living scale (ADL). Secondary clinical outcomes included time of fracture healing and hospital stay, pain score as assessed by visual analogue scale (VAS), and nursing satisfaction.
RESULTS
Before the intervention, there was no significant difference in the indicators of sarcopenia and the indicators of functional independence assessed by ADL between the two groups ( > 0.05). After 3 months of intervention, the BMI, grip strength, calf circumference, pace, and body muscle rate of the patients in the research group were significantly higher than those in the control group ( < 0.05), while body fat rates were significantly lower than those in the control group ( < 0.05), and the capability of eating, walking, bathing, and doing housework in research group were all significantly higher than those in control group ( < 0.05). In addition, the time of fracture healing and hospital stay in research group were all significantly lower than those in control group ( < 0.05), and the VAS scores of the control group at each time point after intervention were significantly higher than those of the research group ( < 0.05). The nursing satisfaction of the patients in the research group was significantly higher than that in the control group (94.00% vs. 76.00%, < 0.05).
CONCLUSION
Nutritional intervention combined with muscle exercise can help improve sarcopenia symptoms and promote fracture recovery in patients with sarcopenic femoral fractures.
目的
研究营养干预联合肌肉锻炼对股骨骨折伴肌肉减少症患者的临床疗效。
方法
本研究纳入了 2019 年 1 月至 2021 年 1 月的 100 例股骨骨折伴肌肉减少症患者，将其分为对照组（常规术后护理）和研究组（营养干预联合肌肉锻炼），每组 50 例。主要临床结局包括肌肉减少症相关指标和日常生活活动量表（ADL）评估的功能独立性。次要临床结局包括骨折愈合时间和住院时间、视觉模拟量表（VAS）评估的疼痛评分以及护理满意度。
结果
干预前，两组患者的肌肉减少症指标和 ADL 评估的功能独立性指标无显著差异（>0.05）。干预 3 个月后，研究组患者的 BMI、握力、小腿围、步速和体肌肉率均显著高于对照组（<0.05），体脂率显著低于对照组（<0.05），且研究组患者的进食、行走、洗澡和做家务能力均显著高于对照组（<0.05）。此外，研究组的骨折愈合时间和住院时间均显著低于对照组（<0.05），且研究组在干预后各时间点的 VAS 评分均显著高于对照组（<0.05）。研究组患者的护理满意度显著高于对照组（94.00%比 76.00%，<0.05）。
结论
营养干预联合肌肉锻炼有助于改善股骨骨折伴肌肉减少症患者的肌肉减少症症状，促进骨折愈合。
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