Jiang You, Li Wenbo, Lu Jun, Zhao Xin, Li Liang
Department of General Surgery, Hefei Second People's Hospital Department of Emergency, the First Affiliated Hospital, Anhui Medical University, Hefei, Anhui Province, People's Republic of China.
Medicine (Baltimore). 2018 Apr;97(14):e0302. doi: 10.1097/MD.0000000000010302.
Recently, several published studies investigating the relationship between protein kinase catalytic subunit alpha-1 gene (PRKAA1) rs13361707 T>C polymorphism and gastric cancer (GC) susceptibility reported controversial results. The purpose of this meta-analysis was to estimate the strength of the relationship.
Qualified studies were identified form a comprehensive search conducted in the Embase, Pubmed, Wangfang, and China National Knowledge Infrastructure (CNKI) databases for studies published before February 12, 2018. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the relationship between the PRKAA1 rs13361707 T>C polymorphism and GC risk.
Fifteen independent case-control studies, which included 14,615 GC patients and 18,143 control subjects, were included in this present meta-analysis. The overall analysis of the 15 studies indicated that the PRKAA1 rs13361707 T>C polymorphism significantly increased susceptibility for GC in all genetic models. When stratified analysis was carried out by country and source of controls, similar results were found in each subgroup, except for the Hispanic Americans. There was no publication bias in our study. Omitting each study 1 at a time in the sensitivity analysis of the PRKAA1 rs13361707 T>C polymorphism and GC risk had no noticeable influence on the pooled OR, which identified the reliability of the meta-analysis. False-positive report probability analysis and trial sequential analysis demonstrated that such relationship was confirmed in the present study.
The meta-analysis reveals that the PRKAA1 rs13361707 T>C polymorphism has a significant relationship with increased GC risk. To confirm the risk identified in the present meta-analysis, well-designed and large-scale case-control studies are warranted to investigate the relationship, especially among non-Asian ethnicity.
最近，几项已发表的研究调查了蛋白激酶催化亚基α-1基因（PRKAA1）rs13361707 T>C多态性与胃癌（GC）易感性之间的关系，报告了相互矛盾的结果。本荟萃分析的目的是评估这种关系的强度。
通过在Embase、Pubmed、万方和中国知网（CNKI）数据库中进行全面检索，确定截至2018年2月12日发表的合格研究。采用合并比值比（OR）和95%置信区间（CI）来评估PRKAA1 rs13361707 T>C多态性与GC风险之间的关系。
本荟萃分析纳入了15项独立的病例对照研究，包括14615例GC患者和18143例对照受试者。对这15项研究的总体分析表明，在所有遗传模型中，PRKAA1 rs13361707 T>C多态性显著增加了GC易感性。按国家和对照来源进行分层分析时，除西班牙裔美国人外，每个亚组均发现了类似结果。我们的研究不存在发表偏倚。在PRKAA1 rs13361707 T>C多态性与GC风险的敏感性分析中，每次逐一剔除一项研究对合并OR没有显著影响，这确定了荟萃分析的可靠性。假阳性报告概率分析和试验序贯分析表明，本研究证实了这种关系。
荟萃分析显示，PRKAA1 rs13361707 T>C多态性与GC风险增加显著相关。为了证实本荟萃分析中确定的风险，有必要开展设计良好的大规模病例对照研究来调查这种关系，尤其是在非亚洲种族中。
