Daunt A O, Cox N L, Robertson J C, Cawley M I
Wessex Rheumatology Research Group.
J R Soc Med. 1987 Sep;80(9):556-8. doi: 10.1177/014107688708000907.
Psoriatic arthritis (PA) may respond to disease-modifying antirheumatic therapy. The value of assessing disease activity with indices devised for rheumatoid arthritis (RA) was investigated in 72 patients with seronegative PA. Thirty patients had a peripheral polyarthritis including the distal interphalangeal joints (DIPJs) and 15 a symmetrical arthritis sparing DIPJs (RA-like). Significant correlations (Spearman rank test) were seen between the clinical variables (pain score, grip strength, Ritchie articular index and a summated index of disease activity) in these two groups. Ten patients with a markedly asymmetrical arthritis showed a poor correlation between clinical variables. Although the objective indices - erythrocyte sedimentation rate (ESR) and C-reactive protein - correlated together in the first two groups, the ESR correlated solely with clinical indices, and then only in RA-like patients. These results cast some doubt on the value of assessment methods based on RA when evaluating subgroups of PA other than RA-like disease.
银屑病关节炎（PA）可能对改善病情的抗风湿治疗有反应。我们对72例血清阴性PA患者进行了研究，探讨使用为类风湿关节炎（RA）设计的指标评估疾病活动度的价值。30例患者患有包括远端指间关节（DIPJ）在内的外周多关节炎，15例患者患有不累及DIPJ的对称性关节炎（类RA）。这两组患者的临床变量（疼痛评分、握力、里奇关节指数和疾病活动度综合指数）之间存在显著相关性（Spearman秩检验）。10例患有明显不对称性关节炎的患者，其临床变量之间的相关性较差。尽管在前两组中，客观指标——红细胞沉降率（ESR）和C反应蛋白——相互相关，但ESR仅与临床指标相关，且仅在类RA患者中如此。这些结果对在评估除类RA疾病之外的PA亚组时基于RA的评估方法的价值提出了一些质疑。
