Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, U.S.A.
Vascular Biology Program, Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA, U.S.A.
Biochem J. 2023 Feb 27;480(4):243-257. doi: 10.1042/BCJ20220303.
The field of mechanobiology, which focuses on the key role that physical forces play in control of biological systems, has grown enormously over the past few decades. Here, I provide a brief personal perspective on the development of the tensegrity theory that contributed to the emergence of the mechanobiology field, the key role that crossing disciplines has played in its development, and how it has matured over time. I also describe how pursuing questions relating to mechanochemical transduction and mechanoregulation can lead to the creation of novel technologies and open paths for development of new therapeutic strategies for a broad range of diseases and disorders.
机械生物学领域专注于物理力量在控制生物系统方面的关键作用，在过去几十年中得到了极大的发展。在这里，我简要地从个人角度介绍一下促成机械生物学领域出现的张力学理论的发展，以及交叉学科在其发展过程中所扮演的关键角色，以及它随着时间的推移是如何成熟的。我还描述了如何通过研究与机械化学转导和机械调节有关的问题，为广泛的疾病和障碍创造新的治疗策略，开辟新的技术和发展途径。
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