Kim Jisun, Chun Bong Ju, Kim Jung Jin
Department of Mechanical Engineering, Keimyung University, Daegu 42601, Republic of Korea.
Cho Chun Shik Graduate School of Mobility, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34051, Republic of Korea.
Biology (Basel). 2023 Jan 20;12(2):170. doi: 10.3390/biology12020170.
Analysis of the dependency of the trabecular structure on loading conditions is essential for understanding and predicting bone structure formation. Although previous studies have investigated the relationship between loads and structural adaptations, there is a need for an in-depth analysis of this relationship based on the bone region and load specifics. In this study, the load dependency of the trabecular bone microstructure for twelve regions of interest (ROIs) in the synthetic proximal femur was quantitatively analyzed to understand the spatial characteristics under seven different loading conditions. To investigate the load dependency, a quantitative measure, called the load dependency score (LDS), was established based on the statistics of the strain energy density (SED) distribution. The results showed that for the global model and epiphysis ROIs, bone microstructures relied on the multiple-loading condition, whereas the structures in the metaphysis depended on single or double loads. These results demonstrate that a given ROI is predominantly dependent on a particular loading condition. The results confirm that the dependency analysis of the load effects for ROIs should be performed both qualitatively and quantitatively.
分析小梁结构对加载条件的依赖性对于理解和预测骨结构形成至关重要。尽管先前的研究已经探讨了载荷与结构适应性之间的关系，但仍需要基于骨区域和载荷细节对这种关系进行深入分析。在本研究中，定量分析了合成近端股骨中十二个感兴趣区域（ROI）的小梁骨微观结构的载荷依赖性，以了解七种不同加载条件下的空间特征。为了研究载荷依赖性，基于应变能密度（SED）分布的统计数据建立了一种定量测量方法，称为载荷依赖性评分（LDS）。结果表明，对于整体模型和骨骺ROI，骨微观结构依赖于多种加载条件，而干骺端的结构则依赖于单载荷或双载荷。这些结果表明，给定的ROI主要依赖于特定的加载条件。结果证实，应对ROI的载荷效应依赖性分析进行定性和定量分析。
