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体外抗牙周炎作用

Antiperiodontitis Effects of In Vitro.

作者信息

Bellere Arce Defeo, Yu Duna, Oh Sarang, Kim Myeongju, Jung Jeyong, Fang Minzhe, Zheng Shengdao, Yi Tae-Hoo

机构信息

Graduate School of Biotechnology, Kyung Hee University, Yongin-si 17104, Republic of Korea.

Snowwhitefactory Co., Ltd., 807 Nonhyeon-ro, Gangnam-gu, Seoul 06032, Republic of Korea.

出版信息

Antioxidants (Basel). 2023 Feb 13;12(2):471. doi: 10.3390/antiox12020471.

DOI:10.3390/antiox12020471
PMID:36830029
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9952020/
Abstract

is generally grown in fields or roadsides in Korea and used for the treatment of inflammatory diseases. The effects of on periodontitis are unknown. In this study, we determined the effects of an 30% EtOH extract (SGE) on periodontitis and analyzed the antioxidant activity (DPPH, ABTS, and SOD), antimicrobial (disc diffusion, MIC, and MBC), inhibition of GTFs, biofilm formation, and the anti-inflammation of lipopolysaccharide from (LPS-PG)-induced primary equine periodontal ligament fibroblasts (PDLFs). We report that SGE increased DPPH, ABTS, and SOD antioxidant activities in a dose-dependent manner. SGE caused a clear zone with a diameter of 15 mm or more against periodontal pathogens. SGE (2.50 mg/mL) inhibited GTFs and biofilm by 89.07% and 85.40%, respectively. SGE treatment (100 µg/mL) also significantly decreased the secretion of inflammatory mediators in sensitized PDLF, including cytokines and matrix metalloproteinase (MMP)-3, -8, -9, and -13. Overall, we confirmed that SGE had excellent antioxidant, antimicrobial, and anti-inflammatory effects against periodontal pathogens. These results suggest that it has the potential to develop as a prophylactic agent for periodontitis.

摘要

在韩国，它一般生长在田野或路边，用于治疗炎症性疾病。其对牙周炎的影响尚不清楚。在本研究中，我们测定了30%乙醇提取物（SGE）对牙周炎的影响，并分析了其抗氧化活性（DPPH、ABTS和SOD）、抗菌活性（纸片扩散法、MIC和MBC）、对葡糖基转移酶（GTFs）的抑制作用、生物膜形成以及对牙龈卟啉单胞菌脂多糖（LPS-PG）诱导的原代马牙周膜成纤维细胞（PDLFs）的抗炎作用。我们报告称，SGE以剂量依赖性方式提高了DPPH、ABTS和SOD的抗氧化活性。SGE对牙周病原体形成了直径为15毫米或更大的清晰抑菌圈。SGE（2.50毫克/毫升）分别抑制GTFs和生物膜达89.07%和85.40%。SGE处理（100微克/毫升）还显著降低了致敏PDLF中炎症介质的分泌，包括细胞因子和基质金属蛋白酶（MMP）-3、-8、-9和-13。总体而言，我们证实SGE对牙周病原体具有优异的抗氧化、抗菌和抗炎作用。这些结果表明它有潜力开发成为一种牙周炎预防剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69f7/9952020/ed41bf22eeee/antioxidants-12-00471-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69f7/9952020/049c14294291/antioxidants-12-00471-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69f7/9952020/bf55d6a768c7/antioxidants-12-00471-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69f7/9952020/ed41bf22eeee/antioxidants-12-00471-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69f7/9952020/9ec0facf7d3a/antioxidants-12-00471-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69f7/9952020/c801ebb3f487/antioxidants-12-00471-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69f7/9952020/9b3ea69ff6b4/antioxidants-12-00471-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69f7/9952020/049c14294291/antioxidants-12-00471-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69f7/9952020/ed41bf22eeee/antioxidants-12-00471-g008.jpg

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Biology (Basel). 2022 Oct 19;11(10):1529. doi: 10.3390/biology11101529.
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The Role of Matrix Metalloproteinases (MMP-8, MMP-9, MMP-13) in Periodontal and Peri-Implant Pathological Processes.基质金属蛋白酶（MMP-8、MMP-9、MMP-13）在牙周和种植体周围病理性过程中的作用。
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Non-communicable Diseases and Oral Health: An Overview.
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The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases.基质金属蛋白酶及其抑制剂在人类疾病中的作用。
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