Institute for Basics Sciences, Faculty of Physiotherapy, University of Physical Education, Krakow, Poland.
University of Physical Education, Krakow, Poland.
Redox Rep. 2021 Dec;26(1):10-17. doi: 10.1080/13510002.2021.1881328.
In obesity, there is a shift in the pro-oxidative-antioxidant balance towards the oxidationreactions. However, it has been shown that in people with normal body composition, after a series of whole-body cryotherapy (WBC), the balance shifts in the opposite direction. The aim of the study was to assess the impact of 20 WBC treatments on blood pro-oxidative-antioxidant balance. Study included 14 obese (BMI > 35) and 10 non-obese volunteers. The total antioxidative (TAS/TAC) and pro-oxidative status (TOS/TOC) in serum and activity of antioxidant enzymes in erythrocytes were determined before the first and 2 hours after the last cryostimulation. In the obese group, a significantly higher level of TOS/TOC, and its significant decrease after the WBC series, was observed. Cryotherapy had no influence on TAS/TAC level which was similar in both groups. Changes in activity of antioxidant enzymes were multidirectional. An increase in CAT activity in the obese group was observed. OSI, both before and after a series of treatments, was significantly higher in obese subjects. A beneficial effect on the level of TOS/TOC and CAT activity was indicated, but the proposed number of treatments for patients with class II obesity turned out to be insufficient. Australian New Zealand Clinical Trials Registry identifier: ACTRN12619000524190.
在肥胖症中，促氧化-抗氧化平衡向氧化反应转移。然而，已经表明，在身体成分正常的人群中，经过一系列全身冷冻疗法（WBC）后，平衡会朝着相反的方向转移。本研究的目的是评估 20 次 WBC 治疗对血液促氧化-抗氧化平衡的影响。研究纳入了 14 名肥胖（BMI>35）和 10 名非肥胖志愿者。在第一次和最后一次冷冻刺激后 2 小时，测定血清中的总抗氧化（TAS/TAC）和促氧化状态（TOS/TOC）以及红细胞中抗氧化酶的活性。在肥胖组中，TOS/TOC 水平显著升高，WBC 系列治疗后显著降低。WBC 治疗对 TAS/TAC 水平没有影响，两组水平相似。抗氧化酶活性的变化是多方向的。观察到肥胖组 CAT 活性增加。OSI 在治疗前后均显著升高，肥胖组更为明显。研究表明，WBC 治疗对 TOS/TOC 水平和 CAT 活性有有益影响，但对于 II 类肥胖患者建议的治疗次数不足。澳大利亚和新西兰临床试验注册中心标识符：ACTRN12619000524190。
