Stanek Agata, Wielkoszyński Tomasz, Bartuś Stanisław, Cholewka Armand
Department and Clinic of Internal Medicine, Angiology and Physical Medicine, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Batorego 15 Street, 41-902 Bytom, Poland.
Higher School of Strategic Planning in Dąbrowa Górnicza, Kościelna 6 Street, 41-300 Dąbrowa Górnicza, Poland.
Antioxidants (Basel). 2020 Dec 21;9(12):1308. doi: 10.3390/antiox9121308.
The purpose of this study was to estimate the effect of whole-body cryostimulation (WBC) and subsequent kinesiotherapy on inflammatory endothelium and oxidative stress parameters in healthy subjects.
The effects of ten WBC procedures lasting 3 min per day and followed by a 60-min session of kinesiotherapy on oxidative stress and inflammatory endothelium parameters in healthy subjects (WBC group = 32) were analyzed. The WBC group was compared to a kinesiotherapy only (KT; = 16) group. The following parameters were estimated one day before the start, and one day after the completion of the studies: oxidative stress parameters (the total antioxidant capacity of plasma (FRAP), paraoxonase-1 activity (PON-1), and total oxidative status (TOS)) and inflammatory endothelium parameters (myeloperoxidase activity (MPO), serum amyloid A (SAA), and sCD40L levels).
A significant decrease of PON-1 and MPO activities and TOS, SAA, and sCD40L levels as well as a significant FRAP increase were observed in the WBC group after the treatment. In addition, the SAA levels and PON-1 activity decreased significantly after the treatment in both groups, but the observed decrease of these parameters in the WBC group was higher in comparison to the KT group.
WBC procedures have a beneficial impact on inflammatory endothelium and oxidative stress parameters in healthy subjects, therefore they may be used as a wellness method.
本研究旨在评估全身冷冻刺激（WBC）及随后的运动疗法对健康受试者炎症性内皮和氧化应激参数的影响。
分析了每天进行10次、每次持续3分钟的WBC程序，随后进行60分钟运动疗法对健康受试者（WBC组 = 32）氧化应激和炎症性内皮参数的影响。将WBC组与仅进行运动疗法（KT； = 16）的组进行比较。在研究开始前一天和结束后一天评估以下参数：氧化应激参数（血浆总抗氧化能力（FRAP）、对氧磷酶-1活性（PON-1）和总氧化状态（TOS））以及炎症性内皮参数（髓过氧化物酶活性（MPO）、血清淀粉样蛋白A（SAA）和可溶性CD40配体（sCD40L）水平）。
治疗后，WBC组观察到PON-1和MPO活性以及TOS、SAA和sCD40L水平显著降低，同时FRAP显著升高。此外，两组治疗后SAA水平和PON-1活性均显著降低，但WBC组这些参数的下降幅度高于KT组。
WBC程序对健康受试者的炎症性内皮和氧化应激参数有有益影响，因此可作为一种保健方法使用。
