Adams Jenna, Ferguson Kaitlin, Hirschy RaeAnn, Konopka Erica, Meckel Jordan, Benanti Grace, Kuhrau Shannon, Albarillo Fritzie, Chang Kevin, Santarossa Maressa, Sapozhnikov Julia, Hoff Brian, Rech Megan A
Department of Pharmacy, Loyola University Medical Center, 2160 S First Ave, Maywood, IL 60153, USA.
Department of Medicine, Division of Infectious Diseases, Loyola University Medical Center, 2160 S First Ave, Maywood, IL 60153, USA.
Antibiotics (Basel). 2023 Feb 1;12(2):295. doi: 10.3390/antibiotics12020295.
Pneumonia is common in the intensive care unit (ICU), infecting 27% of all critically ill patients. Given the high prevalence of this disease state in the ICU, optimizing antimicrobial therapy while minimizing toxicities is of utmost importance. Inappropriate antimicrobial use can increase the risk of antimicrobial resistance, infection, allergic reaction, and other complications from antimicrobial use (e.g., QTc prolongation, thrombocytopenia). This review article aims to discuss methods to optimize antimicrobial treatment in patients with pneumonia, including the following: procalcitonin use, utilization of methicillin-resistant nares testing to determine need for vancomycin therapy, utilization of the Biofire FilmArray pneumonia polymerase chain reaction (PCR), and microbiology reporting techniques.
肺炎在重症监护病房（ICU）很常见，所有重症患者中有27%会受到感染。鉴于这种疾病状态在ICU中的高发病率，在将毒性降至最低的同时优化抗菌治疗至关重要。抗菌药物使用不当会增加抗菌药物耐药性、感染、过敏反应以及抗菌药物使用引发的其他并发症（如QTc延长、血小板减少）的风险。这篇综述文章旨在讨论优化肺炎患者抗菌治疗的方法，包括以下内容：降钙素原的应用、利用耐甲氧西林鼻腔检测来确定是否需要万古霉素治疗、利用Biofire FilmArray肺炎聚合酶链反应（PCR）以及微生物学报告技术。
