Fiatsonu Edem, Busselman Rachel E, Ndeffo-Mbah Martial L
Department of Veterinary Integrative Biosciences, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.
Animals (Basel). 2023 Feb 5;13(4):555. doi: 10.3390/ani13040555.
Chagas disease is a zoonotic vector-borne disease caused by the parasite , which affects a variety of mammalian species across the Americas, including humans and dogs. Mathematical modeling has been widely used to investigate the transmission dynamics and control of vector-borne diseases. We performed a scoping review of mathematical models that investigated the role of dogs in transmission. We identified ten peer-reviewed papers that have explicitly modeled the role of dogs in Chagas transmission dynamics. We discuss the different methods employed in these studies, the different transmission metrics, disease transmission routes, and disease control strategies that have been considered and evaluated. In general, mathematical modeling studies have shown that dogs are not only at high risk of infection but are also major contributors to transmission to humans. Moreover, eliminating infected dogs from households or frequent use of insecticide was shown to be effective for curtailing transmission in both humans and dogs. However, when insecticide spraying is discontinued, infections in dogs were shown to return to their pre-spraying levels. We discuss the challenges and opportunities for future modeling studies to improve our understanding of Chagas disease transmission dynamics and control.
恰加斯病是一种由寄生虫引起的人畜共患媒介传播疾病，影响美洲包括人类和狗在内的多种哺乳动物。数学建模已被广泛用于研究媒介传播疾病的传播动态和控制。我们对研究狗在传播中作用的数学模型进行了范围综述。我们确定了十篇经过同行评审的论文，这些论文明确模拟了狗在恰加斯病传播动态中的作用。我们讨论了这些研究中采用的不同方法、不同的传播指标、疾病传播途径以及已被考虑和评估的疾病控制策略。总体而言，数学建模研究表明，狗不仅感染风险高，而且还是向人类传播的主要贡献者。此外，从家庭中清除感染的狗或频繁使用杀虫剂被证明对减少人类和狗的传播有效。然而，当停止喷洒杀虫剂时，狗的感染率会恢复到喷洒前的水平。我们讨论了未来建模研究在增进我们对恰加斯病传播动态和控制的理解方面所面临的挑战和机遇。
