Andjic Marijana, Bradic Jovana, Kocovic Aleksandar, Simic Marko, Krstonosic Veljko, Capo Ivan, Jakovljevic Vladimir, Lazarevic Nevena
Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders, 34000 Kragujevac, Serbia.
Pharmaceutics. 2024 Oct 8;16(10):1309. doi: 10.3390/pharmaceutics16101309.
Alarming data revealed that 19% to 34% of adults with diabetes mellitus develop chronic wounds, which are characterized by impaired healing and a higher risk of infections. Inspired by the traditional use of immortelle for wound healing and the lack of scientific evidence regarding how it thoroughly influences tissue regeneration, we aimed to formulate a hydrogel loaded with immortelle essential oil and assess its effectiveness on diabetic excision wounds. The rheological properties of the hydrogel, an in vivo safety test, as well as wound healing capacity, were determined in rats with induced diabetes and excision wounds. Diabetic rats were divided into four groups: untreated, treated with 1% silver sulfadiazine ointment, treated with a gel base, and treated with the immortelle essential oil-based hydrogel. It was revealed that the hydrogel exerts pseudoplastic behavior and has no potential to act as an irritant, thus highlighting its suitability for skin application. Moreover, analysis of macroscopic, biochemical, and histopathological data revealed that the immortelle essential oil-based hydrogel significantly improves wound repair. Superior re-epithelialization, scar maturation, and increased collagen fiber density were achieved after immortelle essential oil-based gel application. These findings suggest that the immortelle essential oil-based hydrogel could be a natural, safe, and effective wound-healing dressing.
令人担忧的数据显示，19%至34%的成年糖尿病患者会出现慢性伤口，其特点是愈合受损且感染风险更高。受传统上使用蜡菊促进伤口愈合以及缺乏关于其如何全面影响组织再生的科学证据的启发，我们旨在制备一种负载蜡菊精油的水凝胶，并评估其对糖尿病切除伤口的疗效。在诱导糖尿病并造成切除伤口的大鼠中测定了水凝胶的流变学特性、体内安全性测试以及伤口愈合能力。糖尿病大鼠分为四组：未治疗组、用1%磺胺嘧啶银软膏治疗组、用凝胶基质治疗组和用蜡菊精油基水凝胶治疗组。结果显示，该水凝胶表现出假塑性行为，且无刺激作用，因此突出了其适用于皮肤应用的特性。此外，对宏观、生化和组织病理学数据的分析表明，蜡菊精油基水凝胶显著改善了伤口修复。应用蜡菊精油基凝胶后实现了更好的上皮再形成、瘢痕成熟以及胶原纤维密度增加。这些发现表明，蜡菊精油基水凝胶可能是一种天然、安全且有效的伤口愈合敷料。
