Wang Min, Veeraperumal Suresh, Zhong Saiyi, Cheong Kit-Leong
Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Guangdong Provincial Science and Technology Innovation Center for Subtropical Fruit and Vegetable Processing, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.
Postgraduate College, Guangdong Ocean University, Zhanjiang 524088, China.
Foods. 2023 Feb 18;12(4):878. doi: 10.3390/foods12040878.
Oligosaccharides derived from natural resources are attracting increasing attention as both food and nutraceutical products because of their beneficial health effects and lack of toxicity. During the past few decades, many studies have focused on the potential health benefits of fucoidan. Recently, new interest has emerged in fucoidan, partially hydrolysed into fuco-oligosaccharides (FOSs) or low-molecular weight fucoidan, owing to their superior solubility and biological activities compared with fucoidan. There is considerable interest in their development for use in the functional food, cosmetic, and pharmaceutical industries. Therefore, this review summarises and discusses the preparation of FOSs from fucoidan using mild acid hydrolysis, enzymatic depolymerisation, and radical degradation methods, and discusses the advantages and disadvantages of hydrolysis methods. Several purification steps performed to obtain FOSs (according to the latest reports) are also reviewed. Moreover, the biological activities of FOS that are beneficial to human health are summarised based on evidence from in vitro and in vivo studies, and the possible mechanisms for the prevention or treatment of various diseases are discussed.
源自自然资源的低聚糖因其有益健康且无毒，作为食品和营养保健品正受到越来越多的关注。在过去几十年里，许多研究聚焦于岩藻依聚糖的潜在健康益处。最近，人们对部分水解成岩藻寡糖（FOSs）或低分子量岩藻依聚糖的岩藻依聚糖产生了新的兴趣，因为它们与岩藻依聚糖相比具有更好的溶解性和生物活性。人们对其在功能性食品、化妆品和制药行业的开发应用兴趣浓厚。因此，本综述总结并讨论了使用温和酸水解、酶促解聚和自由基降解方法从岩藻依聚糖制备FOSs的过程，并讨论了水解方法的优缺点。还综述了为获得FOSs而进行的几个纯化步骤（根据最新报道）。此外，基于体外和体内研究的证据总结了FOS对人体健康有益的生物活性，并讨论了预防或治疗各种疾病的可能机制。
