Departamento de Ciências Biológicas, Universidade Federal do Espírito Santo, Vitória 29075-010, Espírito Santo, Brazil.
Departamento de Medicina Social, Universidade Federal do Espírito Santo, Vitória 29040-090, Espírito Santo, Brazil.
Genes (Basel). 2023 Feb 6;14(2):419. doi: 10.3390/genes14020419.
Translational Bioinformatics (TBI) is defined as the union of translational medicine and bioinformatics. It emerges as a major advance in science and technology by covering everything, from the most basic database discoveries, to the development of algorithms for molecular and cellular analysis, as well as their clinical applications. This technology makes it possible to access the knowledge of scientific evidence and apply it to clinical practice. This manuscript aims to highlight the role of TBI in the study of complex diseases, as well as its application to the understanding and treatment of cancer. An integrative literature review was carried out, obtaining articles through several websites, among them: PUBMED, Science Direct, NCBI-PMC, Scientific Electronic Library Online (SciELO), and Google Academic, published in English, Spanish, and Portuguese, indexed in the referred databases and answering the following guiding question: "How does TBI provide a scientific understanding of complex diseases?" An additional effort is aimed at the dissemination, inclusion, and perpetuation of TBI knowledge from the academic environment to society, helping the study, understanding, and elucidating of complex disease mechanics and their treatment.
转化生物信息学（TBI）被定义为转化医学和生物信息学的结合。它涵盖了从最基本的数据库发现到分子和细胞分析算法的开发，以及它们的临床应用等各个方面，是科学技术的重大进步。这项技术使人们能够获取科学证据的知识并将其应用于临床实践。本文旨在强调 TBI 在复杂疾病研究中的作用，以及它在理解和治疗癌症方面的应用。通过几个网站进行了综合文献回顾，获得了英文、西班牙语和葡萄牙语的文章，包括：PUBMED、Science Direct、NCBI-PMC、Scientific Electronic Library Online（SciELO）和 Google Academic，并在上述数据库中进行了索引，回答了以下指导性问题：“TBI 如何提供对复杂疾病的科学理解？”还努力将 TBI 知识从学术环境传播、纳入和延续到社会中，帮助研究、理解和阐明复杂疾病的机制及其治疗方法。
