Chan Soon-Shiong Institute of Molecular Medicine at Windber, Windber, PA 15963, USA.
Murtha Cancer Center/Research Program, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, Bethesda, MD 20889, USA.
Int J Environ Res Public Health. 2023 Feb 7;20(4):2903. doi: 10.3390/ijerph20042903.
Black women in the US have significantly higher breast cancer mortality than White women. Within biomarker-defined tumor subtypes, disparate outcomes seem to be limited to women with hormone receptor positive and HER2 negative (HR+/HER2-) breast cancer, a subtype usually associated with favorable prognosis. In this review, we present data from an array of studies that demonstrate significantly higher mortality in Black compared to White women with HR+/HER2-breast cancer and contrast these data to studies from integrated healthcare systems that failed to find survival differences. Then, we describe factors, both biological and non-biological, that may contribute to disparate survival in Black women.
美国的黑人女性乳腺癌死亡率明显高于白人女性。在基于生物标志物的肿瘤亚型中，不同的结果似乎仅限于激素受体阳性和 HER2 阴性（HR+/HER2-）乳腺癌的女性，这种亚型通常与良好的预后相关。在这篇综述中，我们展示了一系列研究的数据，这些数据表明 HR+/HER2-乳腺癌的黑人女性死亡率明显高于白人女性，并将这些数据与未能发现生存差异的综合医疗保健系统的研究进行了对比。然后，我们描述了可能导致黑人女性生存差异的生物学和非生物学因素。
