Department of Occupational Medicine, Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology, 540142 Târgu Mureş, Romania.
Center for Advanced Medical and Pharmaceutical Research, George Emil Palade University of Medicine, Pharmacy, Science, and Technology, 540142 Târgu Mureş, Romania.
Int J Environ Res Public Health. 2023 Feb 14;20(4):3314. doi: 10.3390/ijerph20043314.
Glyphosate, and the ever growing reliance on its use in agriculture, has been a point of contention for many years. There have been debates regarding the risk and safety of using glyphosate-based herbicides as well as the effects of occupational, accidental, or systematic. Although there have been a number of studies conducted, the biomonitoring of glyphosate poses a series of challenges. Researchers attempting to determine the occupational exposure face questions regarding the most appropriate analytical techniques and sampling procedures. The present review aims to summarize and synthetize the analytical methodologies available and suitable for the purpose of glyphosate biomonitoring studies as well as discuss the advantages and disadvantages of each analytical technique, from the most modern to more well-established and older ones. The most relevant publications that have described analytical methods and published within the last 12 years were studied. Methods were compared, and the advantages and disadvantages of each methods were discussed. A total of 35 manuscripts describing analytical methods for glyphosate determination were summarized and discussed, with the most relevant one being compared. For methods that were not intended for biological samples, we discussed if they could be used for biomonitoring and approaches to adapt these methods for this purpose.
草甘膦及其在农业中日益增长的使用依赖已经引起了多年的争议。关于使用草甘膦除草剂的风险和安全性以及职业、意外或系统性影响存在许多争论。尽管已经进行了许多研究，但草甘膦的生物监测仍然存在一系列挑战。研究人员在试图确定职业暴露时，面临着关于最适当的分析技术和采样程序的问题。本综述旨在总结和综合用于草甘膦生物监测研究的可用和合适的分析方法，并讨论每种分析技术的优缺点，从最现代到更成熟和更古老的技术。研究了过去 12 年内描述分析方法并发表的最相关出版物。对方法进行了比较，并讨论了每种方法的优缺点。总结和讨论了 35 篇描述草甘膦测定分析方法的文章，其中最相关的方法进行了比较。对于不针对生物样本的方法，我们讨论了它们是否可用于生物监测以及为此目的改编这些方法的方法。
