Division of Clinical Anatomy, Department of Anatomy, Faculty of Medicine, Medical University of Gdansk, 80-211 Gdańsk, Poland.
Laboratory of Tissue Engineering and Regenerative Medicine, Division of Embryology, Department of Anatomy, Faculty of Medicine, Medical University of Gdansk, 80-211 Gdańsk, Poland.
Int J Mol Sci. 2023 Feb 15;24(4):3888. doi: 10.3390/ijms24043888.
Adipose-derived mesenchymal stromal cells (AD-MSCs) have been extensively studied in recent years. Their attractiveness is due to the ease of obtaining clinical material (fat tissue, lipoaspirate) and the relatively large number of AD-MSCs present in adipose tissue. In addition, AD-MSCs possess a high regenerative potential and immunomodulatory activities. Therefore, AD-MSCs have great potential in stem cell-based therapies in wound healing as well as in orthopedic, cardiovascular, or autoimmune diseases. There are many ongoing clinical trials on AD-MSC and in many cases their effectiveness has been proven. In this article, we present current knowledge about AD-MSCs based on our experience and other authors. We also demonstrate the application of AD-MSCs in selected pre-clinical models and clinical studies. Adipose-derived stromal cells can also be the pillar of the next generation of stem cells that will be chemically or genetically modified. Despite much research on these cells, there are still important and interesting areas to explore.
近年来，脂肪来源间充质基质细胞（AD-MSCs）受到了广泛的研究。它们的吸引力在于临床材料（脂肪组织、脂肪抽吸物）易于获取，以及脂肪组织中存在相对较多的 AD-MSCs。此外，AD-MSCs 具有较高的再生潜能和免疫调节活性。因此，AD-MSCs 在基于干细胞的创伤愈合治疗以及骨科、心血管或自身免疫性疾病治疗中具有巨大的潜力。目前有许多关于 AD-MSC 的临床试验，在许多情况下已经证明了它们的有效性。在本文中，我们根据我们的经验和其他作者的研究，介绍了 AD-MSCs 的最新知识。我们还展示了 AD-MSCs 在选定的临床前模型和临床研究中的应用。脂肪来源的基质细胞也可以成为下一代经过化学或基因修饰的干细胞的支柱。尽管对这些细胞进行了大量研究，但仍有许多重要和有趣的领域有待探索。
