Graduate Institute of Ph.D. Program in Nutrition and Food Science, Fu-JenCatholic University, New Taipei City, Hsinchuang, Taiwan.
Nutr J. 2012 Jun 13;11:41. doi: 10.1186/1475-2891-11-41.
Type 2 diabetes mellitus is a major global public health problem in the worldwide and is increasing in aging populations. Magnesium intake may be one of the most important factors for diabetes prevention and management. Low magnesium intake may exacerbate metabolic abnormalities. In this study, the relationships of magnesium intake with metabolic parameters, depression and physical activity in elderly patients with type 2 diabetes were investigated.
This cross-sectional study involved 210 type 2 diabetes patients aged 65 years and above. Participants were interviewed to obtain information on lifestyle and 24-hour dietary recall. Assessment of depression was based on DSM-IV criteria. Clinical variables measured included anthropometric measurements, blood pressure, and biochemical determinations of blood and urine samples. Linear regression was applied to determine the relationships of magnesium intake with nutritional variables and metabolic parameters.
Among all patients, 88.6% had magnesium intake which was less than the dietary reference intake, and 37.1% had hypomagnesaemia. Metabolic syndromes and depression were associated with lower magnesium intake (p < 0.05). A positive relationship was found between magnesium intake and HDL-cholesterol (p = 0.005). Magnesium intake was inversely correlated with triglyceride, waist circumference, body fat percent and body mass index (p < 0.005). After controlling confounding factor, HDL-cholesterol was significantly higher with increasing quartile of magnesium intake (p for trend = 0005). Waist circumference, body fat percentage, and body mass index were significantly lower with increase quartile of magnesium intake (p for trend < 0.001). The odds of depression, central obesity, high body fat percentage, and high body mass index were significantly lower with increasing quartile of magnesium intake (p for trend < 0.05). In addition, magnesium intake was related to high physical activity level and demonstrated lower serum magnesium levels. Serum magnesium was not significantly associated with metabolic parameters.
The majority of elderly type 2 diabetes who have low magnesium intake may compound this deficiency with metabolic abnormalities and depression. Future studies should determine the effects of increased magnesium intake or magnesium supplementation on metabolic control and depression in elderly people with type 2 diabetes.
2 型糖尿病是全球范围内一个主要的公共卫生问题，在老龄化人口中呈上升趋势。镁的摄入量可能是预防和管理糖尿病的最重要因素之一。低镁摄入可能会加重代谢异常。在这项研究中，我们研究了镁摄入量与 210 名 65 岁及以上老年 2 型糖尿病患者的代谢参数、抑郁和体力活动之间的关系。
本横断面研究纳入 210 名 2 型糖尿病患者，年龄 65 岁及以上。通过访谈获得生活方式和 24 小时饮食回顾信息。抑郁评估基于 DSM-IV 标准。测量的临床变量包括人体测量、血压和血液、尿液样本的生化测定。线性回归用于确定镁摄入量与营养变量和代谢参数之间的关系。
在所有患者中，88.6%的镁摄入量低于膳食参考摄入量，37.1%的患者存在低镁血症。代谢综合征和抑郁与较低的镁摄入量相关（p<0.05）。镁摄入量与高密度脂蛋白胆固醇呈正相关（p=0.005）。镁摄入量与甘油三酯、腰围、体脂百分比和体重指数呈负相关（p<0.005）。在控制混杂因素后，随着镁摄入量 quartile 的增加，高密度脂蛋白胆固醇显著升高（趋势 p 值=0.0005）。随着镁摄入量 quartile 的增加，腰围、体脂百分比和体重指数显著降低（趋势 p 值<0.001）。随着镁摄入量 quartile 的增加，抑郁、中心性肥胖、体脂百分比高和体重指数高的几率显著降低（趋势 p 值<0.05）。此外，镁摄入量与体力活动水平高有关，并显示出较低的血清镁水平。血清镁与代谢参数无显著相关性。
大多数低镁摄入的老年 2 型糖尿病患者可能会因代谢异常和抑郁而加重这种缺乏。未来的研究应确定增加镁摄入或镁补充对 2 型糖尿病老年患者代谢控制和抑郁的影响。
