Katsos Konstantinos, Johnson Sarah E, Ibrahim Sufyan, Bydon Mohamad
Department of Neurologic Surgery, Mayo Clinic, Rochester, MN 55902, USA.
Mayo Clinic Neuro-Informatics Laboratory, Department of Neurologic Surgery, Mayo Clinic, Rochester, MN 55902, USA.
Life (Basel). 2023 Feb 14;13(2):520. doi: 10.3390/life13020520.
Spinal cord tumors constitute a diverse group of rare neoplasms associated with significant mortality and morbidity that pose unique clinical and surgical challenges. Diagnostic accuracy and outcome prediction are critical for informed decision making and can promote personalized medicine and facilitate optimal patient management. Machine learning has the ability to analyze and combine vast amounts of data, allowing the identification of patterns and the establishment of clinical associations, which can ultimately enhance patient care. Although artificial intelligence techniques have been explored in other areas of spine surgery, such as spinal deformity surgery, precise machine learning models for spinal tumors are lagging behind. Current applications of machine learning in spinal cord tumors include algorithms that improve diagnostic precision by predicting genetic, molecular, and histopathological profiles. Furthermore, artificial intelligence-based systems can assist surgeons with preoperative planning and surgical resection, potentially reducing the risk of recurrence and consequently improving clinical outcomes. Machine learning algorithms promote personalized medicine by enabling prognostication and risk stratification based on accurate predictions of treatment response, survival, and postoperative complications. Despite their promising potential, machine learning models require extensive validation processes and quality assessments to ensure safe and effective translation to clinical practice.
脊髓肿瘤是一组多样的罕见肿瘤,与显著的死亡率和发病率相关,带来了独特的临床和手术挑战。诊断准确性和结果预测对于明智的决策至关重要,可促进个性化医疗并推动优化患者管理。机器学习有能力分析和整合大量数据,从而识别模式并建立临床关联,最终可提升患者护理水平。尽管人工智能技术已在脊柱外科的其他领域得到探索,如脊柱畸形手术,但针对脊髓肿瘤的精确机器学习模型仍滞后。机器学习在脊髓肿瘤中的当前应用包括通过预测基因、分子和组织病理学特征来提高诊断精度的算法。此外,基于人工智能的系统可协助外科医生进行术前规划和手术切除,有可能降低复发风险,从而改善临床结果。机器学习算法通过基于对治疗反应、生存和术后并发症的准确预测进行预后和风险分层来促进个性化医疗。尽管其潜力巨大,但机器学习模型需要广泛的验证过程和质量评估,以确保安全有效地转化为临床实践。